Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories

by Kellaway, SG, Keane, P, Edginton-White, B, Regha, K, Kennett, E, Bonifer, C
Published 2022

Developmental-stage-dependent transcriptional response to leukaemic oncogene expression

by Regha, K, Assi, S.A, Tsoulaki, O, Gilmour, J, Lacaud, G, Bonifer, C
Published 2020

Early chromatin unfolding by RUNX1: A molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program

by Hoogenkamp, M., Lichtinger, M., Krysinska, H., Clarke, D., Ingram, R., Bonifer, C., Lancrin, C., Lacaud, G., Williamson, A., Kouskoff, V., Mazzarella, L., Jorgensen, H., Fisher, A., Tenen, D.G.
Published 2011

Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells

by Leddin, M., Perrod, C., Hoogenkamp, M., Ghani, S., Assi, S., Heinz, S., Wilson, N.K., Follows, G., Schönheit, J., Vockentanz, L., Mosammam, A.M., Chen, W., Tenen, D.G., Westhead, D.R., Göttgens, B., Bonifer, C., Rosenbauer, F.
Published 2016

RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis

by Lichtinger, M., Ingram, R., Hannah, R., Müller, D., Clarke, D., Assi, S.A., Lie-A-Ling, M., Noailles, L., Vijayabaskar, M.S., Wu, M., Tenen, D.G., Westhead, D.R., Kouskoff, V., Lacaud, G., Göttgens, B., Bonifer, C.
Published 2016

RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element

by Levantini, E., Lee, S., Radomska, H.S., Hetherington, C.J., Alberich-Jorda, M., Amabile, G., Zhang, P., Gonzalez, D.A., Zhang, J., Basseres, D.S., Wilson, N.K., Koschmieder, S., Huang, G., Zhang, D.-E., Ebralidze, A.K., Bonifer, C., Okuno, Y., Gottgens, B., Tenen, D.G.
Published 2014

Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding

by Ptasinska, A., Assi, S.A., Mannari, D., James, S.R., Williamson, D., Dunne, J., Hoogenkamp, M., Wu, M., Care, M., McNeill, H., Cauchy, P., Cullen, M., Tooze, R.M., Tenen, D.G., Young, B.D., Cockerill, P.N., Westhead, D.R., Heidenreich, O., Bonifer, C.
Published 2014

Sox4 Is a Key Oncogenic Target in C/EBPα Mutant Acute Myeloid Leukemia

by Zhang, H., Alberich-Jorda, M., Amabile, G., Yang, H., Staber, P.B., DiRuscio, A., Welner, R.S., Ebralidze, A., Zhang, J., Levantini, E., Lefebvre, V., Valk, P.J.M., Delwel, R., Hoogenkamp, M., Nerlov, C., Cammenga, J., Saez, B., Scadden, D.T., Bonifer, C., Ye, M., Tenen, D.G.
Published 2016