Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: Synthesis, evaluation and SAR

by Lee, C.-Y., Chew, E.-H., Go, M.-L.
Published 2014

Studies on the chemical constituents and biological activities of ixeris

by Zhang, Y.-C., He, C.-N., Chew, E.-H.
Published 2014

Pachymic acid impairs breast cancer cell invasion by suppressing nuclear factor-κB-dependent matrix metalloproteinase-9 expression

by Ling, H., Zhang, Y., Ng, K.-Y., Chew, E.-H.
Published 2014

6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-κB activation

by Ling, H., Yang, H., Tan, S.-H., Chui, W.-K., Chew, E.-H.
Published 2014

Antioxidant and Nrf2 inducing activities of luteolin, a flavonoid constituent in Ixeris sonchifolia Hance, provide neuroprotective effects against ischemia-induced cellular injury

by Zhang, Y.-C., Gan, F.-F., Shelar, S.B., Ng, K.-Y., Chew, E.-H.
Published 2014

Inhibition of Hypoxia-Inducible Factor-1α (HIF-1α) Protein Synthesis by DNA damage inducing agents

by Lou, J.J.W., Chua, Y.L., Chew, E.H., Gao, J., Bushell, M., Hagen, T.
Published 2014

Induction of Tumor Cell Death through Targeting Tubulin and Evoking Dysregulation of Cell Cycle Regulatory Proteins by Multifunctional Cinnamaldehydes

by Nagle, A.A., Gan, F.-F., Jones, G., So, C.-L., Wells, G., Chew, E.-H.
Published 2014

Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention

by Chew, E.-H., Nagle, A.A., Zhang, Y., Scarmagnani, S., Palaniappan, P., Bradshaw, T.D., Holmgren, A., Westwell, A.D.
Published 2014

Shogaols at proapoptotic concentrations induce G2/M arrest and aberrant mitotic cell death associated with tubulin aggregation

by Gan, F.-F., Nagle, A.A., Ang, X., Ho, O.H., Tan, S.-H., Yang, H., Chui, W.-K., Chew, E.-H.
Published 2014

Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads

by Kaminska, K.K, Bertrand, H.C, Tajima, H, Stafford, W.C, Cheng, Q, Chen, W, Wells, G, Arner, E.S.J, Chew, E.-H
Published 2020

A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways

by Gan, F.-F., Ling, H., Ang, X., Reddy, S.A., Lee, S.S.-H., Yang, H., Tan, S.-H., Hayes, J.D., Chui, W.-K., Chew, E.-H.
Published 2014

Identification of michael acceptor-centric pharmacophores with substituents that yield strong thioredoxin reductase inhibitory character correlated to antiproliferative activity

by Gan, F.-F., Kaminska, K.K., Yang, H., Liew, C.-Y., Leow, P.-C., So, C.-L., Tu, L.N.L., Roy, A., Yap, C.-W., Kang, T.-S., Chui, W.-K., Chew, E.-H.
Published 2014