Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis

by Ditsworth, D, Maldonado, M, McAlonis-Downes, M, Sun, S, Seelman, A, Drenner, K, Arnold, E, Ling, S.-C, Pizzo, D, Ravits, J, Cleveland, D.W, Da Cruz, S
Published 2020

Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS

by Mitchell, J.C, Constable, R, So, E, Vance, C, Scotter, E, Glover, L, Hortobagyi, T, Arnold, E.S, Ling, S.-C, McAlonis, M, Da Cruz, S, Polymenidou, M, Tessarolo, L, Cleveland, D.W, Shaw, C.E
Published 2020

ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP

by Sun S., Ling S.-C., Qiu J., Albuquerque C.P., Zhou Y., Tokunaga S., Li H., Qiu H., Bui A., Yeo G.W., Huang E.J., Eggan K., Zhou H., Fu X.-D., Lagier-Tourenne C., Cleveland D.W.
Published 2016

Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

by Ling, S.-C., Dastidar, S.G., Tokunaga, S., Ho, W.Y., Lim, K., Ilieva, H., Parone, P.A., Tyan, S.-H., Tse, T.M., Chang, J.-C., Platoshyn, O., Bui, N.B., Bui, A., Vetto, A., Sun, S., McAlonis-Downes, M., Han, J.S., Swing, D., Kapeli, K., Yeo, G.W., Tessarollo, L., Marsala, M., Shaw, C.E., Tucker-Kellogg, G., La Spada, A.R., Lagier-Tourenne, C., Da Cruz, S., Cleveland, D.W.
Published 2021