Vascular immunotargeting to endothelial determinant ICAM-1 enables optimal partnering of recombinant scFv-Thrombomodulin fusion with endogenous cofactor

by Greineder C.F., Chacko A.-M., Zaytsev S., Zern B.J., Carnemolla R., Hood E.D., Han J., Ding B.-S., Esmon C.T., Muzykantov V.R.
Published 2019

A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Soluble Thrombomodulin, ART-123, in Patients With Sepsis and...

by Vincent JL., Ramesh MK., Ernest D., Larosa SP., Pachl J., Aikawa N., Hoste E., Levy H., Hirman J., Levi M., Daga M., Kutsogiannis DJ., Crowther M., Bernard GR., Devriendt J., Puigserver JV., Blanzaco DU., Esmon CT., Parrillo JE., Guzzi L., Henderson SJ., Pothirat C., Mehta P., Fareed J., Talwar D., Tsuruta K., Gorelick KJ., Osawa Y., Kaul I.
Published 2014

A randomized, double-blind, placebo-controlled, phase 2b Study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and...

by Vincent J.-L., Ramesh M.K., Ernest D., Larosa S.P., Pachl J., Aikawa N., Hoste E., Levy H., Hirman J., Levi M., Daga M., Kutsogiannis D.J., Crowther M., Bernard G.R., Devriendt J., Puigserver J.V., Blanzaco D.U., Esmon C.T., Parrillo J.E., Guzzi L., Henderson S.J., Pothirat C., Mehta P., Fareed J., Talwar D., Tsuruta K., Gorelick K.J., Osawa Y., Kaul I.
Published 2014