Gastric cancer pathology and underlying molecular mechanisms

by Grabsch, H.I., Tan, P.
Published 2014

Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer

by Hou, Q., Yong, H.W., Grabsch, H., Zhu, Y., Siew, H.L., Ganesan, K., Cross, D., Lay, K.T., Tao, J., Gopalakrishnan, V., Bor, L.T., Oi, L.K., Tan, P.
Published 2014

Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer

by Matula, K, Collie-Duguid, E, Murray, G, Parikh, K, Grabsch, H, Tan, P, Lalwani, S, Garau, R, Ong, Y, Bain, G, Smith, A.-D, Urquhart, G, Bielawski, J, Finnegan, M, Petty, R
Published 2020

Comprehensive biomarker analyses identifies HER2, EGFR, MET RNA expression and thymidylate synthase 5’UTR SNP as predictors of benefit from S-1 adjuvant chemotherapy in Japanese pa...

by Yoshikawa, T., Aoyama, T., Sakamaki, K., Oshima, T., Lin, J., Zhang, S., Sapari, N.S., Soong, R., Tan, I., Chan, X.B., Bottomley, D., Hewitt, L.C., Arai, T., Teh, B.T., Epstein, D., Ogata, T., Kameda, Y., Miyagi, Y., Tsuburaya, A., Morita, S., Grabsch, H.I., Tan, P.
Published 2021

Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing

by Zang, Z.J., Ong, C.K., Cutcutache, I., Yu, W., Zhang, S.L., Huang, D., Ler, L.D., Dykema, K., Gan, A., Tao, J., Lim, S., Liu, Y., Futreal, P.A., Grabsch, H., Furge, K.A., Goh, L.K., Rozen, S., Teh, B.T., Tan, P.
Published 2013

Technical reproducibility of single-nucleotide and size-based DNA biomarker assessment using DNA extracted from formalin-fixed, paraffin-embedded tissues

by Zhang Shenli, Tan Bee Huat Iain, Nur Sabrina Bte Sapari, Grabsch H.I., Okines A., Smyth E.C., Aoyama T., Hewitt L.C., Inam I., Bottomley D., Nankivell M., Stenning S.P., Cunningham D., Wotherspoon A., Tsuburaya A., Yoshikawa T., Soong Chuan Teck Richie, Tan Boon Ooi Patrick
Published 2016

Tumour expression of leptin is associated with chemotherapy resistance and therapy-independent prognosis in gastro-oesophageal adenocarcinomas

by Bain, G.H., Collie-Duguid, E., Murray, G.I., Gilbert, F.J., Denison, A., McKiddie, F., Ahearn, T., Fleming, I., Leeds, J., Phull, P., Park, K., Nanthakumaran, S., Grabsch, H.I., Tan, P., Welch, A., Schweiger, L., Dahle-Smith, A., Urquhart, G., Finegan, M., Petty, R.D.
Published 2014

KRAS and BRAF mutations are rare and related to DNA mismatch repair deficiency in gastric cancer from the East and the West: Results from a large international multicentre study

by Van Grieken, N.C.T., Aoyma, T., Chambers, P.A., Bottomley, D., Ward, L.C., Inam, I., Buffart, T.E., Das, K., Lim, T., Pang, B., Zhang, S.L., Tan, I.B., Carvalho, B., Heideman, D.A.M., Miyagi, Y., Kameda, Y., Arai, T., Meijer, G.A., Tsuburaya, A., Tan, P., Yoshikawa, T., Grabsch, H.I.
Published 2014

Comprehensive genomic meta-analysis identifies intra-tumoural stroma as a predictor of survival in patients with gastric cancer

by Wu, Y., Grabsch, H., Ivanova, T., Tan, I.B., Murray, J., Ooi, C.H., Wright, A.I., West, N.P., Hutchins, G.G.A., Wu, J., Lee, M., Lee, J., Koo, J.H., Yeoh, K.G., Van Grieken, N., Ylstra, B., Rha, S.Y., Ajani, J.A., Cheong, J.H., Noh, S.H., Lim, K.H., Boussioutas, A., Lee, J.-S., Tan, P.
Published 2014

Oncogenic pathway combinations predict clinical prognosis in gastric cancer

by Ooi, C.H., Tan, P., Ivanova, T., Wu, J., Lee, M., Tao, J., Koo, J.H., Gopalakrishnan, V., Zhu, Y., Lee, J., Ganesan, K., Tan, I.B., Tao, J., Ward, L., Grabsch, H., Cheng, L.L., Rha, S.Y., Chung, H.C., So, J., Soo, K.C., Lim, D., Chan, W.H., Wong, W.K., Bowtell, D., Boussioutas, A., Yeoh, K.G.
Published 2011

A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets

by Deng, N., Goh, L.K., Wang, H., Das, K., Tao, J., Tan, I.B., Zhang, S., Lee, M., Wu, J., Lim, K.H., Lei, Z., Goh, G., Lim, Q.-Y., Tan, A.L.-K., Poh, D.Y.S., Riahi, S., Bell, S., Shi, M.M., Linnartz, R., Zhu, F., Yeoh, K.G., Toh, H.C., Yong, W.P., Cheong, H.C., Rha, S.Y., Boussioutas, A., Grabsch, H., Rozen, S., Tan, P.
Published 2014

Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy

by Tan, I.B., Ivanova, T., Lim, K.H., Ong, C.W., Deng, N., Lee, J., Tan, S.H., Wu, J., Lee, M.H., Ooi, C.H., Rha, S.Y., Wong, W.K., Boussioutas, A., Yeoh, K.G., So, J., Yong, W.P., Tsuburaya, A., Grabsch, H., Toh, H.C., Rozen, S., Cheong, J.H., Noh, S.H., Wan, W.K., Ajani, J.A., Lee, J., Tellez, M.S., Tan, P.
Published 2014