Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer

• Main Authors: Matula, K, Collie-Duguid, E, Murray, G, Parikh, K, Grabsch, H, Tan, P, Lalwani, S, Garau, R, Ong, Y, Bain, G, Smith, A.-D, Urquhart, G, Bielawski, J, Finnegan, M, Petty, R
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2020
• Subjects: antineoplastic agent; biological marker; capecitabine; cisplatin; docetaxel; epirubicin; glycosphingolipid; messenger RNA; oxaliplatin; protein p53; safingol; sphingolipid; sphingosine 1 phosphate; sphingosine 1 phosphate lyase; sphingosine kinase 1; unclassified drug; lyase; lysophospholipid; phosphotransferase; RNA; sphingosine; sphingosine 1-phosphate; sphingosine 1-phosphate lyase (aldolase); sphingosine kinase; Article; cancer cell line; cancer combination chemotherapy; cancer inhibition; cancer patient; cancer staging; cancer surgery; cancer survival; carcinogenesis; cell compartmentalization; controlled study; disease association; drug cytotoxicity; drug efficacy; drug potentiation; drug safety; drug sensitivity; drug tolerability; enzyme regulation; esophageal adenocarcinoma; esophageal squamous cell carcinoma; esophagus cancer; exon; gastroesophageal cancer; gene; gene expression; high performance liquid chromatography; human; human cell; human tissue; IC50; immunohistochemistry; lysosome; monotherapy; multiple cycle treatment; phase 1 clinical trial; protein expression; quantitative analysis; reverse transcription polymerase chain reaction; SGPL1 gene; signal transduction; sphingolipid metabolism; SPHK1 gene; stomach adenocarcinoma; stomach cancer; survival time; analogs and derivatives; biosynthesis; drug resistance; Esophageal Neoplasms; female; gene expression regulation; genetics; male; metabolism; real time polymerase chain reaction; Stomach Neoplasms; tumor cell line; Aldehyde-Lyases; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Lysophospholipids; Male; Phosphotransferases (Alcohol Group Acceptor); Real-Time Polymerase Chain Reaction; RNA, Neoplasm; Signal Transduction; Sphingosine
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/181428
• Institution: National University of Singapore

10.1186/s12885-015-1718-7