In vitro metabolism of leflunomide by mouse and human liver microsomes.

by Chan, E.C., New, L.S.
Published 2014

Evaluation of BEH C18, BEH HILIC, and HSS T3 (C18) column chemistries for the UPLC-MS-MS analysis of glutathione, glutathione disulfide, and ophthalmic acid in mouse liver and huma...

by New, L.-S., Chan, E.C.Y.
Published 2014

Prevention of acetaminophen (APAP)-induced hepatotoxicity by leflunomide via inhibition of APAP biotransformation to N-acetyl-p-benzoquinone imine

by Tan, S.C., New, L.S., Chan, E.C.Y.
Published 2014

Oxidative bioactivation and toxicity of leflunomide in immortalized human hepatocytes and kinetics of the non-enzymatic conversion to its major metabolite, A77 1726

by Seah, Q.M., New, L.-S., Chan, E.C.Y., Boelsterli, U.A.
Published 2014

Ultra-high performance liquid chromatography/time-of-flight mass spectrometry (UHPLC/TOFMS) for time-dependent profiling of raw and steamed Panax notoginseng

by Toh, D.-F., New, L.-S., Koh, H.-L., Chan, E.C.-Y.
Published 2014

Reversible time-dependent inhibition of cytochrome P450 enzymes by duloxetine and inertness of its thiophene ring towards bioactivation

by Chan, C.Y., New, L.S., Ho, H.K., Chan, E.C.Y.
Published 2014

Direct toxicity effects of sulfo-conjugated troglitazone on human hepatocytes

by Saha, S., New, L.S., Ho, H.K., Chui, W.K., Chan, E.C.Y.
Published 2014

Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity

by Saha, S., New, L.S., Ho, H.K., Chui, W.K., Chan, E.C.Y.
Published 2014

Pharmacokinetic study of intraperitoneally administered troglitazone in mice using ultra-performance liquid chromatography/tandem mass spectrometry

by New, L.-S., Saha, S., Boelsterli, U.A., CHAN CHUN YONG,ERIC, Ong, M.M.K.
Published 2011

Pharmacokinetic study of intraperitoneally administered troglitazone in mice using ultra-performance liquid chromatography/tandem mass spectrometry

by New, L.-S., Saha, S., Ong, M.M.K., Boelsterli, U.A., Chan, E.C.Y.
Published 2014

Distribution study of orally administered lipoic acid in rat brain tissues

by Chng, H.T., New, L.S., Neo, A.H., Goh, C.W., Browne, E.R., Chan, E.C.Y.
Published 2014

A sensitive LC/MS/MS bioanalysis assay of orally administered lipoic acid in rat blood and brain tissue

by Chng, H.T., New, L.S., Neo, A.H., Goh, C.W., Browne, E.R., Chan, E.C.Y.
Published 2014

Investigation of the drug-drug interaction between α-lipoic acid and valproate via mitochondrial β-oxidation

by Phua, L.C., New, L.S., Goh, C.W., Neo, A.H., Browne, E.R., Chan, E.C.Y.
Published 2014

Optimizing hollow-fiber-based pharmacokinetic assay via chemical stability study to account for inaccurate simulated drug clearance of rifampicin

by New, L.S., Lim, T.P., Oh, J.W., Cheah, G.J.S., Kwa, A.L., Chan, E.C.Y.
Published 2014

Interaction of lapatinib with cytochrome P450 3A5

by Chan, E.C.Y., New, L.S., Chua, T.B., Yap, C.W., Ho, H.K., Nelson, S.D.
Published 2014

Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib

by Takakusa, H., Wahlin, M.D., Zhao, C., Hanson, K.L., New, L.S., Chan, E.C.Y., Nelson, S.D.
Published 2014

Metabolic profiling of 3-nitropropionic acid early-stage huntingtons disease rat model using gas chromatography time-of-flight mass spectrometry

by Chang, K.L., New, L.S., Mal, M., Goh, C.W., Aw, C.C., Browne, E.R., Chan, E.C.Y.
Published 2014

Mechanism-based inactivation of cytochrome P450 3A4 by lapatinib

by Teng, W.C., Oh, J.W., New, L.S., Wahlin, M.D., Nelson, S.D., Ho, H.K., Chan, E.C.Y.
Published 2014

Pyrrolidinediones reduce the toxicity of thiazolidinediones and modify their anti-diabetic and anti-cancer properties

by Saha, S., Chan, D.S.Z., Lee, C.Y., Wong, W., New, L.S., Chui, W.K., Yap, C.W., Chan, E.C.Y., Ho, H.K.
Published 2014

Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity

by Kashimshetty, R., Desai, V.G., Kale, V.M., Lee, T., Moland, C.L., Branham, W.S., New, L.S., Chan, E.C.Y., Younis, H., Boelsterli, U.A.
Published 2014