Proteins of the Bcl-2 family in apoptosis signalling: From mechanistic insights to therapeutic opportunities

by Chan, S.-L., Yu, V.C.
Published 2014

1-(5-Isoquinolinesulfonyl)-2-methylpiperazine induces apoptosis in human neuroblastoma cells, SH-SY5Y, through a p53-dependent pathway

by Ronca, F., Chan, S.-L., Yu, V.C.
Published 2014

Retinoic acid confers resistance to p53-dependent apoptosis in SH-SY5Y neuroblastoma cells by modulating nuclear import of p53

by Ronca, F., Yee, K.S.Y., Yu, V.C.
Published 2014

Auto-FACE: An NMR based binding site mapping program for fast chemical exchange protein-ligand systems

by Krishnamoorthy, J., Yu, V.C.K., Mok, Y.-K.
Published 2014

A novel BH3-like domain in BID is required for intramolecular interaction and autoinhibition of pro-apoptotic activity

by Tan, K.O., Tan, K.M.L., Yu, V.C.
Published 2014

Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction

by Chen, M., Zhang, Y., Yu, V.C., Chong, Y.-S., Yoshioka, T., Ge, R.
Published 2014

Baxβ: A Constitutively Active Human Bax Isoform that Is under Tight Regulatory Control by the Proteasomal Degradation Mechanism

by Fu, N.Y., Sukumaran, S.K., Kerk, S.Y., Yu, V.C.
Published 2014

Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism

by Kah, F.W., Chan, S.-L., Sukumaran, S.K., Lee, M.-C., Yu, V.C.
Published 2014

Mitochondrial translocation of cofilin is an early step in apoptosis induction

by Chua, B.T., Volbracht, C., Tan, K.O., Li, R., Yu, V.C., Li, P.
Published 2014

RACK1 downregulates levels of the pro-apoptotic protein Fem1b in apoptosis-resistant colon cancer cells

by Subauste, M.C., Ventura-Holman, T., Du, L., Subauste, J.S., Chan, S.-L., Yu, V.C., Maher, J.F.
Published 2014

A Soluble Form of the Pilus Protein FimA Targets the VDAC-Hexokinase Complex at Mitochondria to Suppress Host Cell Apoptosis

by Sukumaran, S.K., Fu, N.Y., Tin, C.B., Wan, K.F., Lee, S.S., Yu, V.C.
Published 2014

The hepatitis C virus core protein contains a BH3 domain that regulates apoptosis through specific interaction with human Mcl-1

by Mohd-Ismail, N.K., Deng, L., Sukumaran, S.K., Yu, V.C., Hotta, H., Tan, Y.-J.
Published 2014

Absence of Stress Response in Dorsal Raphe Nucleus in Modulator of Apoptosis 1-Deficient Mice

by Zhao H., Mohamed N.-E., Chan S.J., Tan C.T., Tao R., Yu V.C., Wong P.T.-H.
Published 2019

A tissue-specific enhancer confers Pit-1-dependent morphogen inducibility and autoregulation on the pit-1 gene

by Rhodes, S.J., Chen, R., DiMattia, G.E., Scully, K.M., Kalla, K.A., Lin, S.-C., Yu, V.C., Rosenfeld, M.G.
Published 2014

A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland

by Jiang, Y., Yu, V.C., Buchholz, F., O'Connell, S., Rhodes, S.J., Candeloro, C., Xia, Y.-R., Lusis, A.J., Rosenfeld, M.G.
Published 2014

TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21

by Zhang, L., Mei, Y., Fu, N.-Y., Guan, L., Xie, W., Liu, H.-H., Yu, C.-D., Yin, Z., Yu, V.C., You, H.
Published 2014

RNF13, a RING finger protein, mediates endoplasmic reticulum stress-induced apoptosis through the inositol-requiring enzyme (IRE1α)/c-jun NH 2-terminal kinase pathway

by Arshad, M., Ye, Z., Gu, X., Wong, C.K., Liu, Y., Li, D., Zhou, L., Zhang, Y., Bay, W.P., Yu, V.C., Li, P.
Published 2014

Structure-activity relationship studies of phenanthridine-based Bcl-X L inhibitors

by Bernardo, P.H., Wan, K.-F., Sivaraman, T., Xu, J., Moore, F.K., Hung, A.W., Mok, H.Y.K., Yu, V.C., Chai, C.L.L.
Published 2014

Modulator of apoptosis 1 (MOAP-1) is a tumor suppressor protein linked to the RASSF1A protein

by Law J., Salla M., Zare A., Wong Y., Luong L., Volodko N., Svystun O., Flood K., Lim J., Sung M., Dyck J.R.B., Tan C.T., Su Y.-C., Yu V.C., Mackey J., Baksh S.
Published 2020

Structural insights into the design of small molecule inhibitors that selectively antagonize Mcl-1

by Bernardo, P.H., Xu, J., Tian, L., Chin, J.S.F., Lim, D.S.W., Chai, C.L.L., Sivaraman, T., Krishnamoorthy, J., Mok, H.Y.K., Wan, K.-F., Sons, C.M., Tong, J.C., Yu, V.C.
Published 2011