Pharmacokinetics of low-dose lopinavir/ritonavir tablet formulation in HIV-1 infected children

• المؤلفون الرئيسيون: Thanyawee Puthanakit, Kiat Ruxrungtham, Chitsanu Pancharoen, Jintanat Ananworanich, Torsak Burunupradah, Arunee Klinklom
• التنسيق: Research Report
• اللغة: English
• منشور في: Chulalongkorn University 2010
• الموضوعات: Pharmacokinetics; HIV-positive children; HIV (Viruses); Lopinavir; Ritonavir; Antiviral agents
• الوصول للمادة أونلاين: https://digiverse.chula.ac.th/Info/item/dc:13561
• المؤسسة: Chulalongkorn University

Methods: This was an open-label, cross-over study of 24 HIV-infected children with HIV RNA < 50 copies/ml comparing PK parameter of standard dose LPV/r and low dose of LPV/r for 4 weeks. LPV dosage was prescribed by body weight band; 25~35 kg: LPV/r 300/75 vs. 200/50 mg, > 35 kg 400/100 vs. 30...