EFEKTIVITAS ANTIRADANG DAN EFEK SAMPING ULSEROGEN DARI INDOMETASIN SETELAH DISALUT OLEH LIPOSOM

• Main Author: Sukartini Parmas Sukria, Tien
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/1007
• Institution: Institut Teknologi Bandung

The effectiveness of encapsulated indomethacin in liposome as an antiinflammatory agent and it sulcerogenicside effect have been investigated. The liposome used was a mixture of egg phosphatidylcholine and cholesterol (63 µmole :9µmole). Encapsulated indomethacin at doses of 2 mg/kg and 4 mg/kg body weight were administrated orally to female albino Wistar rats of 180-200 gm body weight which were fasted for twenty-four hours before the administration of indomethacin, but water was supplied ad libitum. One-tenth milliliters of a suspension of 0, 5% lambda carrageenan in 0,9% NaCl was injected subcutaneously into the plantar tissue of the rat's hind paw half an hour after the administration of indomethacin to induce inflammation. The magnitude of inflammation was determined every half hour fora period of six anda half hours. Twenty-four hours after the administration of indomethacin during which period food was still being withheld and water was supplied ad litum, the rats were sacrificed under ether anesthesia and the stomach of each rat was examined for ulcers. Indomethacin suspension in 5% PGA at the same doses was used to compare the effectiveness of encapsulated indomethacin. The results showed that encapsulated indomethacin at a dose of 2 mg/kg body weight has equivalent antiinflammatory effect with indomethacin at a dose of 4 mg/kg body weight in a suspension of 5% PGA. However, there was no in cidence of ulcers which differed from indomethacin at a dose of 4 mg/kg body weight in a suspension of 5% PGA which had a very high ulcer index; thus liposome as indomethacin drug carrier was more. effective as an antiinflammatory drug than indomethacin suspended in 5% PGA, with relatively much lower ulcerogenic side effect.