#TITLE_ALTERNATIVE#

• Main Author: TRI NURMALA, DEVY
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/10219
• Institution: Institut Teknologi Bandung

Cystic acne is one kind of acne that not appears to surface of the skin and therefore need topical treatment that can penetrate up to the dermis layer. Benzoyl peroxide is antibacteria that can be use to treat this acne. Benzoyl peroxide practically insoluble in water and cause a problem in formulation. One approach to overcome that problem is to make the microemulsion dosage form. This system can enhance the solubility and penetration of the substance to the skin. The aim of this study was to develop the microemulsion of benzoyl peroxide. Microemulsion was made using olive oil, Cremophor EL as surfactant, ethanol 95% and glycerin as cosurfactant. The viscosity of the microemulsion was enhanced by adding hidroxypropil cellulose (HPC) and hidroxypropil methyl cellulose (HPMC) gelling agent. The microemulsion was evaluated by measuring pH, viscosity, and physical stability test at 40oC for 28 days and freeze-thaw method. Diffusion of benzoyl peroxide from the microemulsion was examined using diffusion cell with an artificial Spangler membrane. The result showed that stable and transparent microemulsion was obtained from the composition of 10.5% of olive oil; 48% of Cremophor EL; 20% of glycerin; 21.5% of water, without addition of ethanol 95% . This formulation had 1,5% of benzoyl peroxide loading capacity. HPC and HPMC gelling agent could not be incorporated to the microemulsion. The microemulsion was stable at 40oC for 28 days and 8 cycles of freezethaw. Diffusion of benzoyl peroxide from microemulsion after 3 hours was 45.08%.