#TITLE_ALTERNATIVE#

• Main Author: YUANITA MUFTIZAL (NIM 10704012), FITRIA
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/10461
• Institution: Institut Teknologi Bandung

Drugs which are absorbed in the upper part of gastrointestinal track have limited bioavaibility if administered by conventional oral dosage form. Riboflavin is one of the substances which has narrow absorption window in the upper intestine.Short retention time in this absorption area leads to less optimal absorption. It is required a complicated effort to extend retention time in the small intestine. An approach may be provided by developing sustained release floating riboflavin tablet which extend retention time in the gastric (gastroretentive) and release the drug continuously for long period of time. This study was developing sustained released floating tablet which prepared by effervescent system. The various factors were studied such as the amount of sodium bicarbonate, type of polimer-forming matrix including sodium alginate, xanthan gum, Metolose 60 SH4000 and L-HPC, and the ratio of Metolose and xanthan gum (3:1; 4:1; 5:1; 7:1, 10:1; 15:1; and 20:1). Tablet was evaluated including standard physical characterization, lag time, floating time, and release profile.The release study of riboflavin from the tablet was carried out using USP Apparatus 2 in HCl 0,1N for 12 hours at 50 rpm. The amount of riboflavin released at each time point was measured with UV spectrophotometry at 267nm. Combination of Metolose 60SH4000 and xanthan gum is the most appropriate matrix among others, providing floating property of the tablet. The formula containing 15% sodium bicarbonate and Metolose 60SH4000:xanthan gum 20:1 resulted in lag time less than 1 minute and floating time for 12 hours. The release study of riboflavin from the tablet showed that up to 70% of riboflavin was dissolved in the medium after 12 hours. Floating tablet of riboflavin can be developed using effervescent-matrix system with main excipient containing sodium bicarbonat as effervescent source and combination of Metolose 60SH4000 : xanthan gum as polymer-forming matrix. The tablet showed good characteristics as a floating tablet which were indicated by long floating time and sustained release pattern of the active compound.