Formulation of Ketorolac Tromethamine Microspheres

• Main Author: YUDISTIRA (NIM 10704040), GRACE
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/10505
• Institution: Institut Teknologi Bandung

A number of different particulate systems, such as microcapsules and microspheres, are used in various formulations as drug delivery systems. Gelatin has been widely used as the matrices of microspheres due to its beneficial properties, such as biocompatible, biodegradable, and edible. The aim of this study was to formulate gelatin microspheres of Ketorolac Tromethamine (KT), a potent anti-inflammatory and analgesic agent. Microspheres were prepared using emulsification-crosslinking method, and glutaraldehyde was used as the crosslinker. Formulation of KT microspheres were prepared by varying the gelatin concentrations, stirring speed, and stirring time. Results of crosslinking reaction were evaluated by infrared spectophotometry analysis at wavenumber range of 3500-500 cm-1 to confirm the formation of imine groups. Microspheres were further evaluated for their surface properties using scanning electron microscope (SEM), size distribution, and entrapment efficiency. IR spectrums showed the imine groups at wavenumber of 1654,62 cm-1 for both blank microspheres and KT microspheres. SEM revealed that the microspheres were spherical and have smooth surfaces. Microspheres obtained were polydisperse. Gelatin concentration of 10% (w/w) and stirring speed of 500 rpm for 2 h produced 58.99 % microspheres with the size of 200–400 um. Entrapment efficiency of KT within microspheres was 37.39%+-0,14%. These results showed that gelatin microspheres of KT could be formulated using emulsification-crosslinking method.