TRANSFORMASI SENYAWA - SENYAWA EUGENOL DAN ETIL SINAMAT

• Main Author: windarini, Nurita
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/1063
• Institution: Institut Teknologi Bandung

Phenyl propanoid is a group of potential compounds both from the point of view of chemistry and biology since it has functional groups which can be modified to better physiologically active compounds. In this study, the transformation has been carried out to eugenol and ethyl cinnamate, two of the phenyl propanoid. Eugenol was transformed into its isopropyl ether by Williamson method using a 10 % aqueous solution of sodium hydroxide and isopropyl chloride. The reaction was carried out at room temperature for 20 hours and continued for 4 hours under heating at 45-50°C in a waterbath. The product was purified by preparative TLC. The yield of pure isopropyl eugenol ether was 5.86 %. The mass spectrum showed the molecular ion (M+) at 206 and the iH-NMR spectrum showed peaks at 8 1.32 ppm (doublet) and 8 4.42 ppm (multiplet) for -CH( CH3)2. The ultraviolet spectrum gave Amax. at 232 nm and 281.5 nm, while infrared spectrum gave no absorption at 3500 -i cm . Olefinic epoxidation to ethyl cinnamate in this experiment was carried out using peracetic acid. The acid was prepared by Koubek method which gave the mixture of peracetic acid, acetic acid and hydrogen peroxide. The product of the epoxidation was still a mixture which has not been succeeded to be separated