#TITLE_ALTERNATIVE#

• Main Author: SAIFULLAH AMIN (NIM 10704124), MUHAMAD
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/10957
• Institution: Institut Teknologi Bandung

Oral drug delivery sytem is the most convenient route of drug. However, the physiology of gastrointestinal tract often provides biological barrier. Colonic drug delivery is an alternative route of drug administration. Moreover, this route is suitable for drugs which have problem upon release in upper part of gastrointestinal tract. There are strict requirements for colonic preparation, such as the dosage form should remain intact until reaching colon and retards drug release in upper part of gastro intestinal tract but releases the drug in the colon compartment. The aim of this study is to develop colonic tablet containing ibuprofen as a model of active compound. Tablets were prepared with matrix system using in situ cross-linked alginate. Various factors were studied, including: the chemical form of calcium as crosslinker and the percentage of alginate to guargum. The release profile of ibuprofen from the tablet was carried out using USP type 3 release tester and performed in 3 different mediums, consecutively in HCl pH 1.2 for 1 h, in phosphate buffer pH 6.8 for 4 h, and in phosphate buffer pH 5 until 24 h. The calcium for alginate crosslinking is Ca-asetat. The percentages of Na-alginate producing tablets with good physical characteristic are 5%, 10% and 15%. The best formula which have good release ibuprofen is formula containing 10% alginat which can retards release of ibuprofen during 1 hour in HCL pH 1,2 and 4 hour in phosphate buffer pH 6.8 successively equal to 8.98% and 22.34 % and also can release 50.19% ibuprofen during 19 hour in phosphate buffer pH 5.0. Colonic targeting tablet containing ibuprofen has been developed using matrix system with combination of guargum and in situ cross-linked alginate.