#TITLE_ALTERNATIVE#

• Main Author: RUSDIANA , TENDY
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/11505
• Institution: Institut Teknologi Bandung

Gliclazide is a poorly watersoluble drug, leading to variations in its bioavaibility. The aim of this study is to investigate milling technique using ballmill as a method to enhance the solubility of gliclazide in binary system of gliclazide (1:4). GliclazidePEG 6000 (1:4) was milled using ballmill for 30 minutes, 2, 4, 8, and 16 hours. The result of milled mixture powder characterized by solubility test, infra red spectroscopy, XRPD, DSC, and dissolution test. Sustainedrelease tablet was formulated and dissolution test was done using dissolution test device II. Milling process using ballmill for 30 minutes to 4 hours decreased the solubility rate gliclazide compared to its physical mixture, further milling process (8 to 16 hours) caused increase in gliclazide solubility rate compared to milling at 30 minutes until 4 hours. Changes in gliclazide solubility rate caused by its crystallinity changes during milling process. Dissolution test of sustained release tablet showed that gliclazide dissolution from tablets with gliclazidePEG 6000 (1:4) had more sustained effect than tablets with gliclazide only. It was concluded that milling effect on mixture of gliclazidePEG 6000 (1:4) change the crystallinity of gliclazide in binary system of gliclazidePEG 6000 (1:4) that may affect the solubility rate of gliclazide, but no changes in gliclazide solubility observed. The best solubility rate of gliclazide is given by the 16 hours milling process. <br />