POTENTIOMETRIC STUDY IN PTFE SUPPORTED LIQUID MEMBRANE WITH SECONDARY AMINES AS CARRIER FOR PENICILLIN DETERMINATION

• Main Author: NUR HASANAH (NIM: 20507003), ALIYA
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/11781
• Institution: Institut Teknologi Bandung

Penicilline G or benzylpenicilline is an antibiotic produced by Penicillium notatum mould, which include in the structure a B-lactamic ring and a carboxylic group. Due to its large activity, this antibiotic is often used against both aerobic and anaerobid bacteria, being an important drug used in prevention and treatment of bacteria infections. Its determination in pharmaceutical formulations is very important for quality control that generally required in pharmaceutical industry. The development of pharmaceutical, clinic and environmental analyses has led to the need of chemical sensors which are robust and easy to construct and to miniaturize, and which require no maintenance during the life period. Ion selective electrode (ISE) is a potentiometric electrochemical sensor which capable of recording besides indicating analyte concentration. ISE are the most frequently one due to its selectivity, accuracy dan low detection limit. Based on penicillin analytical method development has been known that determination of penicillin using selective electrode in PTFE supported liquid membrane with secondary amine as carrier never been developed. In order to predict and improve sensitivity and selectivity of the potentiometric response of the ISE, it is necessary to do potentiometric study in membranes to understand charge transfer process kinetic that happened at membrane-solution interface.The aim of the research is to get a membrane which have optimum characteristic as ISE membranes. Besides that, is to developed penicillin ISE in PTFE supported liquid membrane with secondary amine as carrier which have optimum characteristics for analytical measurement