#TITLE_ALTERNATIVE#
Currently, solid dosage forms containing dry extract as active compounds are limited to capsules and conventional tablets. As an alternative product and novel innovation, herbal drugs can be developed into another more practical and efficient solid dasage form, such as effervescent. The purpose of t...
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| Main Author: | |
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/13429 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Currently, solid dosage forms containing dry extract as active compounds are limited to capsules and conventional tablets. As an alternative product and novel innovation, herbal drugs can be developed into another more practical and efficient solid dasage form, such as effervescent. The purpose of this research is to develope effervescent dosage form at ambient condition. Effervescent dosage form can be developed as effervescent pellet which contains green tea extract. Effervescent pellet were formulated using combination of tablets diluents (manitol), optimization of acid (tartaric acid), and bases composition (sodium bicarbonate and sodium carbonate), PVP concentration, in each acid and base pellet. Pellets were prepared by extrusion-spheronization method. The characterization of effervescent pellet, i.e.: taste, disintegration time, cloudiness, degree of foaming, and pH. To study whether the process influence antioxidant activity of green tea extract in the formula, we measured antioxidant activity by DPPH (2,2-diphenyl-1-picryl hydrazyl) method. Formula met effervescent dosage form criteria was composed by 32% tartaric acid, sodium bicarbonate-sodium carbonate combination (14 : 13), and 4% PVP. The antioxidant potency (EC50) of green tea extract in effervescent pellet decreased compared to unformulated extract, i.e. 122.87 ug/ml vs 44.37 ug/ml. Effervescent pellet containing extract can be developed without controlling room humidity and temperature. Formulation of extract into pellet decreased antioxidant activity of the extract. |
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