SYNTHESIS OF MESOPOROUS SILICA NANOPARTICLES BY THE MODIFICATION OF STOEBER METHOD USING CATIONIC SURFACTANT

• Main Author: ALIP FIRMANSAH (NIM : 10508081); Pembimbing 1: Dr. rer. nat. Rino R. Mukti; Pembimbing 2 : Prof
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/14811
• Institution: Institut Teknologi Bandung

Nanomedicine utilizes mesoporous silica nanoparticles to deliver drug because it has large surface area. This properties is ideal to carry large amounts of biogenic agents. In this study, mesoporous silica nanoparticles have been intensively investigated. Nanosilica Stoeber as a controlled material synthesized by Stoeber method that is based on the hydrolysis of tetraethyl orthosilicate (TEOS) using ammonia catalyst under weakly alkaline conditions (pH 9-10). The resulting nanosilica Stoeber has small particle size and large Brunauer-Emmet-Teller (BET) specific surface area of 40-60 nm and 477 m2/g, respectively. The synthesis of mesoporous silica nanoparticle was synthesized by the modification of Stoeber method using cationic surfactant. Benzalkonium Chloride (sanisol) was used as cationic surfactant with purpose to inhibit the aggregation of nanoparticles, hence forming particles with ultralarge surface area, in addition the presence of mesoporosity. Nitrogen physisorption was applied to characterize the product and the results show BET specific surface of 1159 m2/g. Based on this BET value, it is assumed that cationic surfactant Benzalkonium Chloride might lead to the formation of intraparticle mesoporosity. The nanoparticle Stoeber does not show any intrapartcile mesoporore characteristic but showing interparticle mesoporosity as visualized from Scanning Electron Microscopy (SEM).