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This final project discuss about the application of linear algebra in predicting RNA secondary structure due to a single point mutation at nucleotide sequences. Generally, single point mutations that occur in a wildtype RNA sequences can alter it's secondary structure and also can change it...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/15208 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | This final project discuss about the application of linear algebra in predicting RNA secondary structure due to a single point mutation at nucleotide sequences. Generally, single point mutations that occur in a wildtype RNA sequences can alter it's secondary structure and also can change it's functions. There are many possible forms of RNA secondary structures formed by these mutations. Conformational energy concept explains that the structure most likely happened is that has the most negative energy conformation. Graph theory is used to represent the RNA secondary structures into graph form, followed by analyzing it's Laplacian matrix and eigenvalues. Second smallest eigen value or algebraic connectivity is a positive number as a measure of similarity of RNA secondary structure. By grouping the algebraic connectivity of each mutant (using RNAMute) then can be found a single point mutation which resulted in a change of structure into a stable form. |
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