#TITLE_ALTERNATIVE#

• Main Author: OLIVER CANDRA HADYISWANTO (NIM : 13706030); Tim Pembimbing : Dr. Ir. Hermawan Judawisasatra; , INDRA
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/16057
• Institution: Institut Teknologi Bandung

Chitosan fiber is one of the potential fibers that can be used as absorbable monofilament suture. Chitosan fibers have been successfully made in Indonesia, but the fibers have not met the limits on needle attachment standard based on United States Pharmacopeia (USP). The quality of chitosan fibers can be enhanced by using methanol drying treatment at the end of the spinning system and by controlling the demineralization time. This research studies the influence of demineralization time and methanol drying treatment on the diameter, tensile properties and biodegradability of chitosan fibers. <br /> <br /> <br /> <br /> <br /> The raw materials for chitosan synthesis were shrimp shells. Demineralization process variations used in this research were 1 x 2 hours and 3 x 2 hours. Chitosan fibers were produced by means of wet spinning. The characterizations used for analyzing chitosan fiber’s chemical properties were FTIR and XRD. Physical properties characterization was carried out in order to measure the fibers’ diameter, density and viscosity. Tensile test were performed for analyzing tensile strength and elongation as well as in vitro degradation test for analyzing biodegradation properties. <br /> <br /> <br /> <br /> <br /> Chitosan fibers was successfully made with diameter and maximum tensile force of chitosan fibers in a range of 330-460 &#956;m and 5,97-8,66 N, respectively. The fibers produced could be categorized as synthetic abosrbable suture number 0 and 1 according to the USP. Results showed that methanol drying treatment could increase chitosan fiber’s tensile strength by 39 MPa (80,6%); however, it could also increase the biodegradation resistance by 18,32%. It is due to the increase in degree of crystallinity during chemical structure change happened in chitosan from hydrated structure to anhydrate. The increase in fibers’ tensile strength is also due to the diameter reduction occurred in chitosan fibers. By using 3x2 hours demineralization, tensile strength decreased by 50,5 MPa (52,3%) and biodegradation resistance also decreased by 7,1%. It is due to the degradation of chitosan occurred during extended demineralization process.