ISOLATION OF SECONDARY METABOLITE FROM THE LEAVES MACARANGA MECOSTYLIS

• Main Author: MELIA RAMDIANI (NIM: 90509019); Pembimbing : Prof. Dr. Yana Maolana Syah
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/16421
• Institution: Institut Teknologi Bandung

Macaranga is one of the largest genus in the Euphorbiaceae family. Macaranga is spread widely across Indonesian archipelago, especially on Kalimantan island and Irian Jaya. Uniquely, on each region where it grows, this plant has its own unique name based on the typical species. The local community use this plant as compliance to the daily needs such as for building materials, wood dye and glue. Moreover, some specific species are used for traditional herb medicines, including to treat leucorrhoea, gonorrhoe, nephrolithiasis (graveel), dysentery, used as mouthwash, to cure the wounds, used as one of ingredient of traditional herb medicine for maternity and reduces toothache. Based on previous studies, genus Macaranga contains a variety of derivatives flavonoids, terpenoids and stilbenoids. Some of these secondary metabolites have biological activity as anti-inflammatory, antioxidant, antiproliferative, and alpha-glucosidase inhibitors (AGIS). Although many studies has been conducted on researching Macaranga species, but in Indonesia it has carried out in just the last three years. So far, there is no studies have been reported on the secondary metabolites of Macaranga mecostylis leaves. In this study, a nimfaeol C compound has been isolated from extract aceton of Macaranga mecostylis leaves. The isolation stages included extraction with acetone, fractination and purification using various chromatographic techniques. The structure of nimfaeol C determined based on spectroscopic data including 1H-NMR and 13C-NMR and comparing to 1H-NMR compound data previously found. This is very important in providing information about secondary metabolites contained in Macaranga plant.