VACCINE DESIGN : COMPUTATIONAL STUDY FOR STABILITY DETERMINATION OF CONJUGATE POLYSACCHARIDE TYPHOID – DIPHTHERIA TOXOID BASED ON QUANTUM MECHANIC THEORY

Vaccine is the antigenic material used to produce active immunity against a disease that can prevent or reduce the effect of infection by natural organisms. Typhoid fever is a major cause of morbidity in the world with an estimated prevalence of between 16-30 million cases and cause 500,000 to 700,0...

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Main Author: FAHLESA FATAHILAH (NIM : 10508016); Pembimbing : Muhamad Abdulkadir Martoprawiro, Ph.D , M.
Format: Final Project
Language:Indonesia
Online Access:https://digilib.itb.ac.id/gdl/view/16434
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Institution: Institut Teknologi Bandung
Language: Indonesia
id id-itb.:16434
spelling id-itb.:164342017-09-27T11:42:31ZVACCINE DESIGN : COMPUTATIONAL STUDY FOR STABILITY DETERMINATION OF CONJUGATE POLYSACCHARIDE TYPHOID – DIPHTHERIA TOXOID BASED ON QUANTUM MECHANIC THEORY FAHLESA FATAHILAH (NIM : 10508016); Pembimbing : Muhamad Abdulkadir Martoprawiro, Ph.D , M. Indonesia Final Project INSTITUT TEKNOLOGI BANDUNG https://digilib.itb.ac.id/gdl/view/16434 Vaccine is the antigenic material used to produce active immunity against a disease that can prevent or reduce the effect of infection by natural organisms. Typhoid fever is a major cause of morbidity in the world with an estimated prevalence of between 16-30 million cases and cause 500,000 to 700,000 deaths per year. Efforts are needed to obtain the vaccine with a higher immunity against the virus of typhoid. Polysaccharide typhoid (Vi) is used as a conjugate <br /> <br /> <br /> <br /> <br /> <br /> <br /> vaccine to provide better durability immunity against typhoid virus. Computational chemistry methods allow to obtain the physico-chemical properties of molecules are modeled, so that it can be used to obtain the profile information of compounds and reactivity of molecules-in this case Vi-DT conjugate molecules. Stability determination of Vi-DT conjugate made with theory <br /> <br /> <br /> <br /> <br /> <br /> <br /> of quantum mechanics using NWCHEM. Three amino acids in a protein-diphteria typhoid is lysine, glutamic acid, aspartic acid and its binding energy is calculated by polysaccharide based on its ability to bind covalently. Another thing that counted among its stability is formilchloride with three amino acids to form a typhoid-diphteria toxoid. Of the three amino acids, lysine <br /> <br /> <br /> <br /> <br /> <br /> <br /> binds with formilchloride most stable, while the most stable glutamic acid binds to the polysaccharide. text
institution Institut Teknologi Bandung
building Institut Teknologi Bandung Library
continent Asia
country Indonesia
Indonesia
content_provider Institut Teknologi Bandung
collection Digital ITB
language Indonesia
description Vaccine is the antigenic material used to produce active immunity against a disease that can prevent or reduce the effect of infection by natural organisms. Typhoid fever is a major cause of morbidity in the world with an estimated prevalence of between 16-30 million cases and cause 500,000 to 700,000 deaths per year. Efforts are needed to obtain the vaccine with a higher immunity against the virus of typhoid. Polysaccharide typhoid (Vi) is used as a conjugate <br /> <br /> <br /> <br /> <br /> <br /> <br /> vaccine to provide better durability immunity against typhoid virus. Computational chemistry methods allow to obtain the physico-chemical properties of molecules are modeled, so that it can be used to obtain the profile information of compounds and reactivity of molecules-in this case Vi-DT conjugate molecules. Stability determination of Vi-DT conjugate made with theory <br /> <br /> <br /> <br /> <br /> <br /> <br /> of quantum mechanics using NWCHEM. Three amino acids in a protein-diphteria typhoid is lysine, glutamic acid, aspartic acid and its binding energy is calculated by polysaccharide based on its ability to bind covalently. Another thing that counted among its stability is formilchloride with three amino acids to form a typhoid-diphteria toxoid. Of the three amino acids, lysine <br /> <br /> <br /> <br /> <br /> <br /> <br /> binds with formilchloride most stable, while the most stable glutamic acid binds to the polysaccharide.
format Final Project
author FAHLESA FATAHILAH (NIM : 10508016); Pembimbing : Muhamad Abdulkadir Martoprawiro, Ph.D , M.
spellingShingle FAHLESA FATAHILAH (NIM : 10508016); Pembimbing : Muhamad Abdulkadir Martoprawiro, Ph.D , M.
VACCINE DESIGN : COMPUTATIONAL STUDY FOR STABILITY DETERMINATION OF CONJUGATE POLYSACCHARIDE TYPHOID – DIPHTHERIA TOXOID BASED ON QUANTUM MECHANIC THEORY
author_facet FAHLESA FATAHILAH (NIM : 10508016); Pembimbing : Muhamad Abdulkadir Martoprawiro, Ph.D , M.
author_sort FAHLESA FATAHILAH (NIM : 10508016); Pembimbing : Muhamad Abdulkadir Martoprawiro, Ph.D , M.
title VACCINE DESIGN : COMPUTATIONAL STUDY FOR STABILITY DETERMINATION OF CONJUGATE POLYSACCHARIDE TYPHOID – DIPHTHERIA TOXOID BASED ON QUANTUM MECHANIC THEORY
title_short VACCINE DESIGN : COMPUTATIONAL STUDY FOR STABILITY DETERMINATION OF CONJUGATE POLYSACCHARIDE TYPHOID – DIPHTHERIA TOXOID BASED ON QUANTUM MECHANIC THEORY
title_full VACCINE DESIGN : COMPUTATIONAL STUDY FOR STABILITY DETERMINATION OF CONJUGATE POLYSACCHARIDE TYPHOID – DIPHTHERIA TOXOID BASED ON QUANTUM MECHANIC THEORY
title_fullStr VACCINE DESIGN : COMPUTATIONAL STUDY FOR STABILITY DETERMINATION OF CONJUGATE POLYSACCHARIDE TYPHOID – DIPHTHERIA TOXOID BASED ON QUANTUM MECHANIC THEORY
title_full_unstemmed VACCINE DESIGN : COMPUTATIONAL STUDY FOR STABILITY DETERMINATION OF CONJUGATE POLYSACCHARIDE TYPHOID – DIPHTHERIA TOXOID BASED ON QUANTUM MECHANIC THEORY
title_sort vaccine design : computational study for stability determination of conjugate polysaccharide typhoid ãƒâ€šã‚– diphtheria toxoid based on quantum mechanic theory
url https://digilib.itb.ac.id/gdl/view/16434
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