#TITLE_ALTERNATIVE#

• Main Author: EKASARI (NIM : 13707056); Dosen Pembimbing : Dr. Ir. Bambang Sunendar, NOVIANTI
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/16722
• Institution: Institut Teknologi Bandung

One of the cancer treatment that has been developed is a method of hyperthermia, a method for cancer treatment by heating cancer tissue to temperatures of 44-45 °C. To <br /> <br /> <br /> <br /> <br /> optimize the hyperthermia process, it is necessary to do some research and development on magnetic nanoparticle which will play an important role in the process of New Drug Delivery System. Magnetic nanoparticle have this characteristic as a superparamagnetic materials that make it easy to be delivered to cancer cells because cancer cells will have a lot of magnetotactic bacteria that could be a compass of nanoparticles on the NDDS process. The structure of the active surface of the nanoparticles can also enhance the effectiveness of heat absorption in the process of hyperthermia. In this study, nickel nanoparticles were synthesized by adding a certain amount of CTAB surfactant by using wet chemical method and metal reduction technique. Reduction process has been carried out by reductor agent named, hydrazine, at temperature 80 ± 2OC with waterbath system. Stage of the synthesis consists of mixing the reactants, including precursors (NiCl2.6H2O solid precursor and CTAB powders), reductor agent, as well as the catalyst to form a black nickel nanoparticle precipitation. The reaction ends when the solution has turned into colorless and produced nitrogen gas.The ratio of nickel and CTAB surfactant (Ni/CTAB) was varied by 1:1, 1:0.4, 1:0.3, 1:0.2, and 1:0.1. The concentration of <br /> <br /> <br /> <br /> <br /> CTAB surfactant was set above critical micelle concentration or technically above 10- 4 M. Sample that have the highest magnetic moment will been capsulated by chitosan to enhance its use as related to its biocompability for New Drug Delivery System process. The characterization results by X-Ray Diffraction (XRD) indicate that all samples synthesized by using a waterbath system produce single-crystalline nickel phase. Scanning Electron Microscopy (SEM) showed the morphology of nickel <br /> <br /> <br /> <br /> <br /> particles produced from this study are nanosphere, irregular shape, nanostar, nanoflower and microsphere with the smallest grain size is 20nm and the largest one is about 6&#956;m. Vibrating Sample Magnetometer (VSM) showed the hysteresis loop that shows superparamagnetic material characteristics with a close to zero value of coercivity and remanence. Nickel nanoparticles coated by chitosan has also already been made, and the appereance of chitosan on nickel nanoparticles can be seen from the main functional groups of chitosan in samples by Fourier Transform Infra-Red (FTIR). FTIR results also showed the persistence of the CTAB remaining in the sample. The formation of chitosan-encapsulated nickel magnetic nanoparticles with superparamagnetic material characteristics and tens of nanometers in size makes this material synthesized in this study can be applied as a supporting material for optimizing hyperthermia.