#TITLE_ALTERNATIVE#

• Main Author: TANUWIJAYA (NIM : 13309007); Pembimbing : Prof. Dr. Ir. Bambang Sunendar, M.Eng.; Ir. Ahmad N, FRANK
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/20115
• Institution: Institut Teknologi Bandung

Reduction of side effects in the treatment of bone cancer can be done by using multi-therapy. Multi-therapy technique is a method of merging bone graft surgery, <br /> <br /> hyperthermia therapy, and natural chemotherapy drugs. Those therapy techniques has shortcomings, which can be supplemented by utilizing the scaffold encapsulated magnetic nanoparticles as drug carriers as well as media for new bone tissue to grow. <br /> <br /> In this research, the magnetic nanoparticles encapsulated scaffold has been made by the method of co-precipitation and freeze drying. Superagnetic nanoparticles is synthesized using Ca(NO3)2, Al(NO3)3, FeCl3, chitosan, and starch. The temperature of calcination is kept at 750oC for two hours. The results will be mashed to powder form and become the main component of scaffold. The encapsulation process is done be mixing the powders with magnetic nanoparticles powder, alginate, chitosan, and mangosteen karbonate apatite without variation. Homogeneous mixture is inserted into the freeze dryer to attract the fluid trapped in the mixture so that it formed a porous material. Mataerials were characterized by optical microscope, Scanning Electron Microscopy (SEM), Vibrating Sample Magnetometer (VSM), Fourier Transform Infrared (FTIR), dan X-ray Difrraction (XRD). <br /> <br /> The synthesized Nanoparticle has diameter 1-10 nm with saturation magnetization of 85 emu/g. It is in complance with the standard size of commercial magnetic nanoparticles for hyperthermia therapy. Freeze drying process doesn't eliminate magnet activity indicated there's force against permanent magnetic field. <br /> <br /> Chemical bond analysis showed that mangosteen as an active anti-cancer compounds are still in the scaffold. Scaffold' porosity looks well distributed with <br /> <br /> pore's diameter 100-300 &#956;m, and has met the standard pore sizes of bone.