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Scaffold is a bone-like material to facilitate the newly bone to grow. The compatibility of scaffold to bone is utmost characteristic that can be used to replace the dysfunctional bone due to cancer. This material is specifically benefit to complement other technique in bone implant. <br />...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/20342 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Scaffold is a bone-like material to facilitate the newly bone to grow. The compatibility of scaffold to bone is utmost characteristic that can be used to replace the dysfunctional bone due to cancer. This material is specifically benefit to complement other technique in bone implant. <br />
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In this research scaffold material was developed by freeze drying method using alginate, chitosan, carbonate apatite, and mangostin. Alginat and chitosan with appropriate volume ratio of 2 : 1 was mixed thoroughly to become gel. Carbonate apatite of 0.1 gram was poured to the mixed gel. Mangostin solution which was extracted from purple-mangosteen with 0.01 and 0.1 g/ml solubility and 1-2 ml volume was added. Material pore and its distributions were measured from its surface morphology using SEM (Scanning Electrone Microscope), whilts bonding characteristic was observed using FTIR (Fourier Transform Infrared Spectroscope). <br />
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It is found that the pore size is relatively unchanged with mangostin solubility and its volume. However, pore distribution is sensitive to the changes of mangostin solubility. Optimal pore distribution is obtained by addition of 0.01 g/ml solubility with volume of 2 ml. This scaffold pore is comparable to the commercial one (100-300 μm). |
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