#TITLE_ALTERNATIVE#

• Main Author: ARIF EKAPUTRA (NIM : 13310079), PRIMADHYA
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/20405
• Institution: Institut Teknologi Bandung

Superparamagnetic Fe3O4 nanoparticles possess certain properties which turns it into a type of utilizable material for the new drug delivery system in hyperthermia therapy for cancer and also as a contrast agent in MRI. In this research, the synthesis of Fe3O4 is done using tapioca powder as a template, which is then encapsulated using chitosan and alginate and impregnated with mangosteen, through co-precipitation method and calcination at 500° C for two hours. The concentration of the precursors are at 0.005 M. The resulting powder shows superparamagnetic characteristics which are directly visible from the attraction of the powder towards a permanent magnetic source. The result of SEM testing shows that the formation of nanorod particles is obtainable through the synthesizing process in which the volume ratio of starch and chitosan solution is kept at 1: 2. FTIR testing results indicate the presence of Fe-O group derived from Fe3O4 in the whole sample as well as other absoption areas from chitosan, alginate, and mangosteen on the encapsulated samples, indicating that the encapsulation process was successful and that it does not affect the characteristics of the Fe3O4 produced. The results of XRD test show the presence of characteristic peaks of Fe3O4 which appear on all the test samples, showing that the results of the synthesis does contain Fe3O4. The VSM test results shows a magnetization moment of 48.7 emu/g, remanence of 10 emu/g, and coercivity of 0.02 Tesla on the pure Fe3O4 sample, and a magnetization moment of 47.5 emu/g, remanence of 10.8 emu/gram, and coercivity of 0.01 Tesla on the Fe3O4 sample which has been encapsulated to the final stage, which also indicates that the encapsulation formed is thin enough, hence the insignificant loss of magnetic quality.