TREATMENT EFFECT ON VIRAL DYNAMICS OF DENGUE FEVER IN THE HUMAN BODY

• Main Author: ZULFA (10113011), ANNISA
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/21154
• Institution: Institut Teknologi Bandung

Dengue fever disease, or commonly called dengue fever, is high risked disease enough in the world. This disease is caused by dengue virus that is spreaded by Aedes aegypti mosquito vector. Dengue virus usually attacks monocytes cell. Infected monocytes cell will produce interpheron for giving a signal to immune system that will activate immune cell and produce antibody. The aim of this final project is deciding dengue infection model to immune respons of body. This model is about differential equation system with five dimensions that represents change the number of suspectible monocytes, infected monocytes, free virus particles, antibodies,nd cell T in 1&#956;L blood. This model has reproductive ratio number, Ro, that represents the number of newly infected cells that arise from any one infected cell when almost all cells are uninfected. If Ro < 1 then the disease will be clear out of the body, but if Ro > 1 the disease will be endemic in the body. <br /> <br /> <br /> Infected cells are monocytes. Involved immune cells are B cells and cytotoxic T cells. The number of involved immune cells are less than lymphocte cells. Unit of time is on days. The variables of model are positive. Treatment is given when first infection occur. Infection model shows that infected cells can clear out of the body on 14 days and infected cells can increase the number of T cells in the body. <br /> <br /> <br /> In the end of 2013, research team of UNAIR discover dengue medicine succesfully, named Melaleuca Alternifolia Concentrate (MAC), that has characteristic of <br /> <br /> <br /> removing virus and acting as immunomodulator. It gives a motivation for doing this final project to know treatment effect on dynamical infection model. Treatment model is constructed with 6 compartements that adopts infection model, that is differential equation system with adding a compartement of changing medicine density. Numerical simulation of treatment model indicate that treatment can decrease the number of infected cells bigger than with no-treatment and increase the number of T cells. It represents the characteristic of MAC medicine. <br /> <br /> <br /> First infection model and also treatment model still have some weakness, infection model has not represented activation of T cells and B cells in the body yet and there <br /> <br /> <br /> is no lysis factor in the change of free virus particles. Then, infetion model and treatment model are modified with considering immunomodulator characteristic of <br /> <br /> <br /> MAC. Adding special assume to infection model can represent immune respon on dengue virus better than before. Three kinds of treatment model are constructed to <br /> <br /> <br /> get the best treatment. They are treatment model with constant function, treatment model with 6 compartements, and treatment control with optimal control. All treatment <br /> <br /> <br /> models do not analyze deeply, only explore it to get first idea for knowing treatment effect on dynamical of dengue infection. Three models have strengthness and also weakness. The result of numerical simulations indicate that treatment can decrease the number of infected cells and increase the number of T cells in the body better than no treatment. The reccomendation of treatment model is treatment with optimal control because this treatment can decrease the number of infected cells more optimal than two other treatment.