#TITLE_ALTERNATIVE#

• Main Author: RISALATI (10712028), AZIFA
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/21363
• Institution: Institut Teknologi Bandung

Glimepirid is a type 2 diabetes drug that is absorbed in the upper gastrointestinal tract. One <br /> <br /> constraint for drugs that absorbed in the upper gastrointestinal tract is a relatively short <br /> <br /> stomach residence time. This can make incomplete of drug absorbed and decreased the <br /> <br /> bioavailability of drug. One approach to prolong and control gastric residence time is <br /> <br /> by preparing gastroretentive drug delivery system such as floating dosage form. The aim of <br /> <br /> this study is to develop glimepirid controlled release floating microspheres by using <br /> <br /> emulsion solvent evaporation method. The formula that used consists of glimepirid as the <br /> <br /> active ingredient, ethyl cellulose and HPMC as a microsphere-forming polymer, Tween 80 as <br /> <br /> emulsifying agent and ethanol and dichloromethane as polymer solvent. Evaluation of the <br /> <br /> microspheres were done for the entrapment efficiency, the rendemen, the appearance of <br /> <br /> microsphere, the particle size, the floating ability, the surface morphology , and the <br /> <br /> release of glimepirid from the microsphere. The best formula in this study is F9 that <br /> <br /> consists of ethyl cellulose: Glimepirid (1: 1) with the value of entrapment efficiency was <br /> <br /> 72.36±2.01%. Rendemen of this formula was 77.9%. The mean particle size of the F9 <br /> <br /> microspheres was 83.38±53.33&#956;m. After 12 hours, about 61.87 ± 2.11% of the microspheres <br /> <br /> were still float in the simulation gastric fluid medium. The morphology of the surface of <br /> <br /> the microspheres revealed by scanning electron microscope showed that the microspheres <br /> <br /> were sphere-shaped with rough surfaces. The amount of glimepirid released from the F9 <br /> <br /> microsphere after 12 hours was 50.09 ± 0.56%.