STUDY ON POLYVINYLPYRROLIDONE (PVP)- EXTRACT TURMERIC SUBMICRON PARTICLES SYNTHESIZED BY USING ELECTROHYDRODYNAMIC ATOMIZATION METHOD

• Main Author: MUSTIKASARI (NIM : 20215017), DEWI
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/21688
• Institution: Institut Teknologi Bandung

Polyvinylpyrrolidone (PVP)-turmeric extract submicron particles, which are potentially applied as drug delivery, have been succesfully synthesized by using electrohydrodyncamic atomization (EHDA) devices. Scanning electron microscope(SEM) images show nanoparticles forming. Obtained nanoparticles diameters are 720 nm, 754 nm, 765 nm, and 787 nm, for ratio 5:2, 5:3, 5:4, dan 5:5, respectively. The diameter value decreases to the increasing of conductivity (&#963;), viscosity (&#951;), and surface tension (&#947;) values of precursor solutions. Besides, obtained particle-size control is close to that of theory. Fourier-transform infrared (FTIR) spectra of the particles for all mass ratio show the presence of PVP dan turmeric extract. For both PVP and turmeric extract, observed interaction modes are vibrations at high wavenumber and stretch at low wavenumber values. Hydroxil (-OH) peak in PVP dan turmeric extract shifts to lower wavenumber. X-ray diffraction (XRD) measurement results show that turmeric extract is dominated by curcumin dan bisdemethoxycurcumin policrystalline, and PVP has amorphous structure. PVPturmeric extract particles have amorphous structure without any significant peak of curcumin and bisdemethoxycurcumin. This indicates deformations in <br /> <br /> policrystalline in turmeric extract due to the bonding with PVP. Glass transition of PVP-TUR nanoparticles is at 166.4ºC lower that that of PVP (172.8ºC). Besides, overall relative mass changes (40ºC to 230ºC) of PVP-turmeric extract nanoparticles is higher than that of PVP and turmeric extract. Antioxidant activity measurement results show the increasing of antioxidant activity of PVP-turmeric <br /> <br /> extract particles by the increasing of turmeric extract mass. This is indicated by the decreasing of IC50 value from 16.4 &#956;g/mL to 10.5 &#956;g/mL for the ratio 5:1 and 5:5. <br /> <br /> Interestingly, IC50 value is linearly decreased to the ratio of turmeric extract and PVP masses. This research shows the presence of PVP that envelopes the drug as turmeric extract in as nanoparticles and potentially applied as antioxidant.