#TITLE_ALTERNATIVE#
Salicylic acid in topical preparations is used as anti-acne at 0.5-2% concentration, and generally cause side effects of skin irritation due to its repeated use. Controlled release preparations, such as microsponge particles, are expected to release active ingredient in a controlled manner so will p...
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| Format: | Final Project |
| Language: | Indonesia |
| Online Access: | https://digilib.itb.ac.id/gdl/view/22353 |
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| Institution: | Institut Teknologi Bandung |
| Language: | Indonesia |
| Summary: | Salicylic acid in topical preparations is used as anti-acne at 0.5-2% concentration, and generally cause side effects of skin irritation due to its repeated use. Controlled release preparations, such as microsponge particles, are expected to release active ingredient in a controlled manner so will prevent the accumulation of active ingredient on the skin surface and might lead in reducing the side effects of skin irritation. This study was aimed to formulate a topical preparation of microsponge salicylic acid 2% gel and evaluate its ability to reduce the side effects of skin irritation. Microsponge is a porous microsphere particle made by quasi-emulsion solvent diffusion method. Microsponges with highest encapsulation efficiency were obtained using 5 mL internal phase solvent consisted of dichloromethane:ethanol (4:1), ethylcellulose: salicylic acid (1: 1, 300 mg: 300 mg), and Tween 80 2% as an emulsifier. The mixture was stirred at 1500 rpm for 1.5 hours. Evaluation of microsponge showed that particles sized 184.85 ± 35.13 μm with a porous surface, with encapsulation efficiency of 93.11 ± 0.48% and production yield of 56.69 ± 1.10%. Formulation using HPMC 2.25% of microsponge gel resulted in a clear, non-sticky gel, with microsponge particles homogenically dispersed up to 28 days of storage. This salicylic acid microsponge gel showed a pH of 4.80 ± 0.82 and a viscosity of 128000 ± 5291.50 cPoise. Drug release from the microsponge system indicated slower release up to 5 hour. Diffusion test using snake snake skin membrane (Phyton reticulatus) showed that drug release from microsponge gel followed zero-order kinetics, with diffusion and swelling matrix release mechanism. Side effects test showed that microsponge gel could reduce the incidence of irritant side effects up to 6-7 days of repeated use, when compared to conventional salicylic acid gel which showed irritation effect after its first application in rabbit test animal. |
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