MOLECULARLY IMPRINTED POLY(METHYL RED) MODIFIED CARBON PASTE ELECTRODE FOR VOLTAMMETRIC DETERMINATION OF RANITIDINE

• Main Author: (NIM : 20513066), RUSTIANINGSIH
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/24136
• Institution: Institut Teknologi Bandung

Ranitidine is widely used for gastric or "maag" treatment. Ranitidine inhibits the action of histamine and reduces gastric acid secretion. Determination of ranitidine requires a simple, accurate, sensitive, and low cost method. In this study, we developed carbon paste electrodes (CPE) modified with molecularly imprinted poly(methyl red) as working electrode for voltammetric determination of ranitidine. Methyl red was electropolymerized on the surface of CPE using cyclic <br /> <br /> <br /> voltammetry technique from solution containing 2 mM methyl red, 1 mM ranitidine and phosphate buffer pH 7. In this process, five cycles of electrode potential was applied in the range of 0.2 V - 1.5 V with scan rate of 100 mV/s. The calibration curve was linearin the concentration range of 0.01 mM - 1.00 mM with a detection limit of 7.96 &#956;M. Interference study showed that ranitidine determinations were not interfered by amoxicillin, ascorbic acid, glycine and paracetamol. Determination of ranitidine in drug samples showed good accuracy with percent recovery between 97,29% - 103,00%.