FABRICATION OF MANGOSTEEN PERICARP EXTRACT (MPE) PARTICLES WITH POLYVINYLPYRROLIDONE (PVP) MATRIX BY ELECTROSPRAY METHOD

• Main Author: AGUNG REZEKI (NIM : 20215010), YULIANTO
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/24820
• Institution: Institut Teknologi Bandung

Mangosteen or Garcinia mangostana L. is a fruit that grows widely in Southeast Asia including Indonesia. The pericarp of the mangosteen contains antioxidant compounds, such as α-mangostin. In practice, the solubility of the compound is very low. Therefore, a conductive matrix is required to improve the solubility of the compound. In this research, polyvinylpyrrolidone (PVP) was used as the matrix of mangosteen pericarp extract (MPE) due to its high solubility. Electrospray (ES) method was applied to synthesize nanoparticles of PVP/MPE. It is a synthesis method of nanoparticles by applying a high electrical field between the positive needle tip and the grounded collector. To control the nanoparticles formation of PVP/MPE, the composition of precursor solution was varied while keeping other parameters to be constant. By analyzing the Scanning Electron Microscope (SEM) images of the obtained nanoparticles, it was found that the average diameter of nanoparticles made from the PVP:MPE precursor solutions with weight ratios of 10:4, 10:6, 10:8, and 10:10 were 640, 706, 710, and 741 nm, respectively. Electrical conductivity of the precursor solution affected the formation of nanoparticles. From the analysis of Fourier transform infrared (FTIR) spectra, it was shown that the addition of the MPE caused additional O-H group in the particles of PVP/MPE. Therefore, it was indicated that MPE was successfully encapsulated in PVP. The effect of flowrate on the formation of nanoparticles was also analyzed in this study. The particles prepared by the flowrates of 2, 3, 4, and 5 μL/m had the average size of 710, 1214, 1461, and 1534 nm, respectively. The greater the flowrate, the larger the particles formed. The content of α-mangostin in PVP/MPE particles prepared by the flowrates of 2, 3, and 4 μL/m were 8, 9, and 12%, respectively. For larger particles, α-mangostin contained was greater as well. The IC70 value of Vitamin-C, MPE paste, and PVP/MPE at ratio of 10:8 and flow rate of 3 μL/m samples were 3,98; 46,29; and 136,39 ppm, respectively, in which the smaller IC70 value indicated greater antioxidant activity.