SYNTHESIS OF TETRAFLUOROBORATE (BF4-), PERCHLORATE (ClO4-), AND HEXAFLUOROPHOSPHATE (PF6-) SALT OF Mn(III)-SALEN COMPLEXES AS MIMIC ENZYME SUPEROXIDE DISMUTASE (mSOD)

• Main Author: NURRAHMAJANTI NIM:20515032, ASIYAH
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/25857
• Institution: Institut Teknologi Bandung

Mn(III)-salen complexes has been reported to exhibit as mimic enzyme superoxide dismutase (mSOD) that could avoid superoxide free radical inside the body. In general, the application of mSOD is still limited only modification in ligand structure, whereas modification of its counter anion is still lack. In this research, the synthesis of Mn(III)-salen complexes with various counter anion that is tetrafluoroborate (BF4-), perchlorate (ClO4-), and hexafluorophosphate (PF6-) from Mn(OAc)2.4H2O and H2salen ligand in methanolic solution according to in-situ method has been succeded. Due to characterization report of the product, revealed that [Mn(salen)BF4] is a complexes with one nuclear inside its structure and its contain BF4- anion that coordinate to atomic center in its axial position like the [Mn(salen)OAc] complexes. However, complexes with ClO4- and PF6- showed dimeric structure where the anion of ClO4- and PF6- are neutralizing the charge of the complexes and OAc act as bridging ligand for two monomer. Based on the elemental analysis and ESI-MS, the molecular formula for both complexes are [Mn2salen2(H2O)(OAc)](ClO4)(H2O) and [Mn2salen2(H2O)(OAc)](PF6)(3,5H2O). The three complexes are paramagnetic with four unpaired electron in the d-orbital for Mn(III) ion. This is supported by the value of their magnetic moment ranges from 5.06 – 5.18. Based on mSOD test, those complexes with the concentration of 1.5 ?M have a potential to inhibit the superoxide reduction with % inhibition ranged between 54 – 72 % with the sequences of mSOD potential from highest to the lowest are [Mn(salen)BF4] > [Mn2salen2(H2O)(OAc)](PF6)(3.5H2O) > [Mn2salen2(H2O)(OAc)](ClO4)(H2O).