Modification of Carbon Paste Electrode with Molecularly Imprinted Poly(glycine) for Voltammetric Determination of Paracetamol

• Main Author: LESTARI BR SURBAKTI (NIM : 10512083), CITRA
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/26295
• Institution: Institut Teknologi Bandung

<p align="justify">Paracetamol is an analgesic and antipyretic compound that is regularly used to reduce fever and backache. If consumed in excessive dose, it may cause reye's sindrome, hepatoxicity and nephrotoxicity. In this study, a voltammetric method for paracetamol determination has been developed by modifying carbon paste electrode with moleculary imprinted poly(glycine). The modification was made through electropolymerisation of glycine in 0,1 M HClO4 solution containing mixture of 1 mM parasetamol, 1 mM glycine. Cyclic voltammetry technique was used for electropolymerization in the potential range of -0.5 V to 1.8 V at a scan rate of 100 mV/s. Repeated measurements of 0.1 M paracetamol provided peak current with %RSD of 2.43 % (n=38) showing good precision of the electrode. The calibration curves showed good linearity in the concentration range of 20 &#956;M - 100 &#956;M with detection limit of 1.82 &#956;M. The modified electrodes had been applied to determine parasetamol in commercial drugs samples with good accuracy (percent recovery of 96.17 % - 104.9 %) and the results were in accordance with those of spectrophotometric method.<p align="justify">