Encapsulation Fe3O4-Mangosteen with Nanocellulose for Therapeutic Application of Cancer

• Main Author: Andini Norma Gupita (13314068), Rian Bernard (13314084), Cornelia
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/26318
• Institution: Institut Teknologi Bandung

<p align="justify">Mangosteen is an active antioxidant compound which is obtained by extracting mangosteen peel (Garcinia Mangostana L.). Mangosteen has potential for cancer drugs since it does not eliminate normal cells in the body. Currently, a widely used cancer drug is Asparaginase, although the drug does not only invade cancer cells, but also attack normal cells. This is due to unencapsulated drugs. Thus, the technique of mangosteen encapsulation can be an alternative solution. In this study, nanoencapsulation began with the isolation and hydrolysis of cellulose from pineapple fibers, Fe3O4 synthesis, and ended with the synthesis of Fe3O4 nanocapsule and mangostin. Encapsulation is done by utilizing chitosan, alginate, and nanoselulose. Characterization of the material bonds using FTIR (Fourier Transform Infrared Spectrophotometry), morphology with TEM (Transmission Electron Microscopy) and SEM (Scanning Electron Microscopy), and pH test using UV-Vis (Ultraviolet Visible Spectroscopy). The results obtained from the characterization showed that Fe3O4 nanocapsule and mangostin were successfully synthesized. Nanoselulose is a whisker with a diameter of 13 ± 2 nm and a length of 120 ± 55 nm, while the nanocapsule is spherical with a diameter of 153 ± 23 nm. Fe3O4 in nanocapsule has a spherical shape with a diameter of 128 ± 38 nm. In the characterization of the pH test, it was shown that the nanocapsule did not release the drug at pH 7.4 (body pH representation) and released the drug at pH 4 (cancer pH representation) instead. Thus, nanocapsule has been successfully made to be sensitive to cancer cells only. <p align="justify"> <br />