Potency of Complex Cu(II)-Salicylaldehyde Dinitrophenylhydrazine and Cu(II)-Benzaldehyde Dinitrophenylhydrazine as Antioxidants

• Main Author: NURWAHYU BIMA 10513085, DAMAR
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/26348
• Institution: Institut Teknologi Bandung

<p align="justify">Schiff base ligand of (E)-2-((2- (2,4-dinitrophenyl) hydrazono) methyl phenol (SDPH) and (E)-1-benzyliden-2-(2,4-dinitrophenyl) hydrazine (BDPH) has been successfully synthesized and used to form complex compounds Cu(II). The SDPH ligand was synthesized from salicylaldehyde precursors and 2,4-dinitrophenylhydrazine, while the BDPH ligand was synthesized from benzaldehid precursors and 2,4-dinitrophenylhydrazine. Both synthesized ligands have been characterized by TLC, melting point and IR spectroscopy. In TLC analysis, the eluent used was n-hexane:ethyl acetate (7:3) (v/v), n-hexane:chloroform (7: 3) (v/v) and n-hexane:acetone (8:2) (v/v). The TLC results showed that each of the ligands SDPH and BDPH is different from the precursors. The SDPH ligand has a melting point of 254-255&#730;C, while the melting point of the BDPH ligand of 234-235&#730;C. The IR spectrum measurements showed the presence of C=N functional groups absorptions in both ligands. The results of 1H NMR 500 MHz and 13C NMR 125 MHz characterizations for both ligands in the DMSO solvent showed that both ligands have been successfully synthesized. The synthesis of complex Cu(II) with ligands SDPH and BDPH was performed by reflux method for about 6 hours and using etanol as solvent. The synthesis of Cu(II)-SDPH complex has a dark brown color, while the Cu(II)-BDPH complex is brown. The result of UV-Vis measurements of both complex showed maximum absorption at 384 nm. The presence of coordination bonds between Cu(II) ions with ligand donor atoms was indicated by the wavenumber shifts of C=N and OH functional groups in the Cu(II)-SDPH complex, whereas in the Cu(II)-BDPH complex observed only by wavenumber shifts of C=N functional group. Both complex compounds are paramagnetic, with the magnetic moment values of Cu(II)-SDPH and Cu(II)-BDPH were 2.00 Bohr Magneton (BM) and 1.87 BM respectively. The bioactivity test showed that the Cu(II) complex compounds have potency as a better antioxidant than its ligands.<p align="justify">