#TITLE_ALTERNATIVE#

• Main Author: NIM : 10714019, FANNY
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/27144
• Institution: Institut Teknologi Bandung

Diabetes Mellitus (DM) is a metabolic disorder characterized by hyperglycemia. WHO has reported <br /> <br /> that diabetes was the cause of 1.6 million death in 2015. Many patients who suffered from diabetes <br /> <br /> used herbs as a complementary or alternative medicine. Previous studies have shown <br /> <br /> antihyperglycemic activity of mangosteen rind extract (EM) containing &#945;-mangostin (AM). The aim of <br /> <br /> this research was to evaluate the utilization of EM and AM multiple doses and determine possibility <br /> <br /> of pharmacokinetic and pharmacodynamic interaction of single dose metformin (MFN) with either <br /> <br /> pure AM or EM. This research was performed on alloxan-induced diabetic Wistar rats. EM (248 mg/kg <br /> <br /> BW/day) and pure AM (37.2 mg/kg BW/day) were given as multiple doses for 14 days, whereas MFN <br /> <br /> was given as a single dose (100 mg/kg BW/day). The study was performed in 5 groups, which received <br /> <br /> EM, pure AM, combination of EM and MFN, combination of pure AM and MFN, and the fifth group as <br /> <br /> control, respectively. MFN and AM concentrations in plasma were determined using HPLC. Plasma <br /> <br /> glucose levels were measured by GOD-PAP method. Pharmacokinetic parameters of MFN and AM and <br /> <br /> AAC values were calculated. MFN administration did not affect the AM pharmacokinetics of both <br /> <br /> extract and pure form following 14 days administration. EM that was given in 14 days affected the <br /> <br /> distribution and clearance of MFN while the pure AM did not give any effect. The administration of <br /> <br /> 14 days of pure AM had a better blood sugar lowering effect (AAC increased by 104%) than pure AM <br /> <br /> 14 days combined with MFN but differed insignificantly if given in EM form. The administration of AM <br /> <br /> in the pure form (AAC increased by 59%) was better than in the EM form. <br />