#TITLE_ALTERNATIVE#

• Main Author: AYU ASMARINI NIM : 11614009 , HANINA
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/27697
• Institution: Institut Teknologi Bandung

Schizophrenia is a mental illness in which the patient loses connection with reality, known as psychotic <br /> <br /> symptoms. Symptoms in schizophrenia disorder distributed into three forms which are positive, negative, <br /> <br /> and cognitive symptoms. Positive symptoms could be marked with hallucination, delusion, and <br /> <br /> disorganized thoughts and movements. Negative symptoms were related with emotional and behavioral <br /> <br /> disorder while cognitive symptoms were related with difficulty in understanding information, focusing, <br /> <br /> and concentrating. Primary pharmacological therapy used in schizophrenic disorder is antipsychotic <br /> <br /> either from first generation (typical), second generation (atypical), or aripiprazole. Irrational use of <br /> <br /> antipsychotic and its sudden discontinuation without caution could lead to problems such as <br /> <br /> exacerbation of the psychotic symptoms, adverse effects, and development of withdrawal syndrome. <br /> <br /> The aim of this research was to evaluate the pattern and accuracy of antipsychotic and anticholinergic <br /> <br /> prescriptions, at the Islamic Mental Hospital of Klender. Anticholinergic evaluation was done as its <br /> <br /> utilization in almost all of the patients to treat Extrapyramidal Syndrome (EPS). The evaluation was <br /> <br /> based on observation of right indication, right drug, and right dose. Drug use evaluation was done by <br /> <br /> referring to both drug use criteria and guidelines. This research was a descriptive and observational <br /> <br /> study, carried out retrospectively using inpatient medical record in the period between January 2017 and <br /> <br /> January 2018. The data was collected from a total of 184 subjects. Demographic data showed 106 males <br /> <br /> and 78 females patient were collected with the majority of ages is early adults. The majority of diagnoses <br /> <br /> collected was paranoid schizophrenia with EPS (72.83%). Drugs from another class therapy such as <br /> <br /> anti-manic, anti-anxiety, and antidepressant were used as adjuvant therapy along with antipsychotic and <br /> <br /> anticholinergic. The most common drugs prescribed were Risperidone and Clozapine carried out 83.70% <br /> <br /> and 83.15% respectively. The result showed that the three most common drug prescribing patterns 1) <br /> <br /> Benzodiazepine, atypical antipsychotic, typical antipsychotic, anticholinergic (26.09%); 2) Atypical <br /> <br /> antipsychotic, typical antipsychotic, anticholinergic (22.08%) and 3) Atypical antipsychotic, <br /> <br /> anticholinergic (20.65%). The result further demonstrated that the rate of right indication, right drugs, <br /> <br /> and right dose with regard to the use of antipsychotic and anticholinergic were 87.50%, 4.97%, and <br /> <br /> 96.27%, respectively. <br />