TWO DIMENSIONAL MODELLING OF RED BLOOD CELL DEFORMABILITY USING GRANULAR MODEL

• Main Author: YASIFA (NIM : 10214086), ISMI
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/28160
• Institution: Institut Teknologi Bandung

In this research, deformability of red blood cell modelled using spring granular model. Red blood cell membranes modelled consisting of 50 granular particles connected by spring. Each particle has a spring force, force from internal hydrostatic pressure, and viscous force. Modelling in this research is using JavaScript and HTML programming language. In this research, the effect of elastic parameters which are spring constant and spring length, also the effect of blood plasm viscosity on red blood cell deformability analyzed. Variation in spring length and spring constant determining shape of red blood cell. In this research, three variations in spring length and spring constant did, which resulting three kinds of red blood cell shapes, those are biconcave, ellipsoid, and sphere. Variation in spring length also shows the deformation that can occur, that is the area compression, area expansion, and shape deformation of red blood cell. Variation in spring constant shows that the greater the spring constant, the faster the deformation time. Variation in blood plasm viscosity shows that the greater the blood plasm viscosity, the longer the deformation time. This simulation shows that biconcave shape has greater defromability, then ellipsoid shape, and spherical shape. This shows from deformation that can occur and how long the deformation time. Deformation time is time needed to deform into initial shape. Thus, this modelling can use to study the deformability of red blood cell in normal and disorder conditions.