#TITLE_ALTERNATIVE#

• Main Author: APRILIA K. S. NIM : 10714084, KATARINA
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/28403
• Institution: Institut Teknologi Bandung

Solubility enhancement of ibuprofen and paracetamol in water through inclusion complexation <br /> <br /> with &#946;-cyclodextrin (BCD), hydroxypropyl-&#946;-cyclodextrin (HPBCD) and its combination with <br /> <br /> hydroxypropyl-methylcelullose (HPMC) had been studied. In the experiment, concentrations of <br /> <br /> cyclodextrin which had been used were around 0 –15 mM and the concentration of HPMC was <br /> <br /> 0,1% w/v. The experiment was studied using phase solubility technique which described by Higuchi <br /> <br /> and Connors. The phase solubility analysis of ibuprofen in BCD aqueous solution resulted as B type <br /> <br /> of phase solubilty diagram, while phase solubility analysis of ibuprofen in HPBCD aqueous solution <br /> <br /> resulted as A type. The phase solubility analysis of paracetamol in both BCD aqueous solution and <br /> <br /> HPBCD aqueous solution resulted as A type of phase solubility diagram. The highest solubility of <br /> <br /> ibuprofen which could be achieved was 1,67 ± 0,03 mg/mL with enhancement factor 26,5. The high <br /> <br /> solubility of ibuprofen was achieved by making inclusion complex with HPBCD and HPMC 0,1% w/v. <br /> <br /> The highest solubility of paracetamol which could be achieved was 31,41 ± 1,02 mg/mL with <br /> <br /> enhancement factor 2,15. The highest solubility of paracetamol was achieved by making inclusion <br /> <br /> complex with BCD and HPMC 0,1% w/v. While it had enhanced the solubility of ibuprofen and <br /> <br /> paracetamol, addition of HPMC in the making of inclusion complex with cyclodextrin hadn’t gave a <br /> <br /> significant result. <br />