SYNTHESIS AND CHARACTERIZATION OF ZN(II)-OXIDOBENZYLIDENE AMINOPROPANOATE AND ZN(II)-OXIDOBENZYLIDENE AMINOACETATE COMPLEXES, AND ITS INHIBITION STUDIES ON Α- AMYLASE

• Main Author: YONATHAN SURYANA (NIM:10514017), MICHAEL
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/28906
• Institution: Institut Teknologi Bandung

Nowadays, the potential of complex compounds in medical applications has been studied by <br /> <br /> many researchers. Many complexes of Zn(II) with Schiff base derivative have been synthesized <br /> <br /> and its potential as antidiabetic type 2 have been studied. In this research, synthesis of Zn(II)- <br /> <br /> (E)-2-((2-oxidobenzylidene)amino)propanoate complex (Zn(II)-OBAP complex) and Zn(II)-(E)- <br /> <br /> 2-((2-oxidobenzylidene)amino)acetate complex (Zn(II)-OBAA complex) have been conducted. <br /> <br /> Both complexes were synthesized with stoichiometry ratio Zn(II):salicylaldehyde:amino acid = <br /> <br /> 1,0:1,0:1,1. Both complexes were synthesized in situ. 1H-NMR analysis result of Zn(II)-OBAP <br /> <br /> complex showed a singlet signal at chemical shift of 8,38 ppm, while a singlet signal at chemical <br /> <br /> shift of 8,37 ppm visible in 1H-NMR spectrum of Zn(II)-OBAA. Those singlet signals originated <br /> <br /> from H atom in the imine functional group, which is present in each ligand. FTIR spectrum of <br /> <br /> Zn(II)-OBAP complex showed an imine peak at wavenumber 1623 cm-1, while imine peak at <br /> <br /> wavenumber 1644 cm-1 was observed on FTIR spectrum of Zn(II)-OBAA. Furthermore, on both <br /> <br /> spectra, no aldehyde vibration peak was observed. This indicated that the salicylaldehyde have <br /> <br /> reacted with the amino acid. Based on the analysis of Zn content by AAS, Zn(II)-OBAP <br /> <br /> complex was predicted to have the molecular formula [ZnL1(H2O)].4H2O (L1 = OBAP Ligand), <br /> <br /> while the Zn(II)-OBAA complex was predicted to have the molecular formula <br /> <br /> [ZnL2(H2O)].4H2O (L2 = OBAA Ligand). Bioactivity assay using -amylase showed that both of <br /> <br /> complexes cannot inhibit -amylase activity in vitro.n vitro.