#TITLE_ALTERNATIVE#

• Main Author: FAUZIAH RAHMAN NIM: 20716015 , NOER
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/29699
• Institution: Institut Teknologi Bandung

Metabolic syndrome is a group of complex metabolic disorder which is one of the <br /> <br /> risk factors for cardiovascular disease. It consists of central obesity, dyslipidemia, <br /> <br /> hypertension, and increase in plasma glucose levels. Raphanus sativus (White <br /> <br /> Radish) has been traditionally used to treat a variety of conditions, including <br /> <br /> metabolic syndrome. Therefore, the aim of this study was to determine the <br /> <br /> therapeutic activity of white radish bulb juice as an agent of metabolic syndrome in <br /> <br /> Danio rerio (zebrafish) induced by high carbohydrate. White Radish Bulbs were <br /> <br /> prepared by made white radish juice and dried it using spry dryer with addition of <br /> <br /> arabic gum (3%). The test concentration used in this study was 22% (LP1), <br /> <br /> 47%(LP2), and 97% (LP3). Orlistat 0.5 mM was used as a drug comparison for 40 <br /> <br /> days. The results showed the body weight and Body Mass Index (BMI) in three <br /> <br /> concentrations increased of 66.46%; 55,56%; 54.49% and 23,51%; 15,47%; <br /> <br /> 16,13% respectively compared to pain control (70.88% and 18.90%). In addition, <br /> <br /> the result of several biochemical parameters showed the LP2 group had <br /> <br /> significantly lower glucose levels than the pain group. While the LP2 and LP3 <br /> <br /> groups showed significantly lower triglyceride levels than the pain group. However, <br /> <br /> all test groups did not affect the parameters of total cholesterol and High Density <br /> <br /> Lipoprotein-C (HDL-C). Based on the results of this study, it can be concluded that <br /> <br /> white radish bulbs showed therapeutic activity in the metabolic syndrome therapy <br /> <br /> in zebrafish. <br />