#TITLE_ALTERNATIVE#

• Main Author: IRWAN FAUZI NIM: 20715024, NOVI
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/29728
• Institution: Institut Teknologi Bandung

Background and Objectives: Diabetes mellitus is one of diseases that still provide the <br /> <br /> challenges for the health world. Suppress the prevalence and control dangerous complications <br /> <br /> effects is one of the efforts that must be done. Most patient have type 2 diabetes. The Conditions <br /> <br /> in this type of diabetes is insulin resistance, caused by the high intake of fat into body. White <br /> <br /> turmeric (Curcuma zedoaria [Christm.] Roscoe) can potentially inhibit the occurrence of <br /> <br /> insulin resistance because it is known to have antihiperlipidemia effect. It is strategically used <br /> <br /> as an antidiabetic drug whose effect has also been widely studied. This study aims to prove and <br /> <br /> know the mechanism of white turmeric extract on inhibiting the occurrence of insulin resistance <br /> <br /> in experimental animals. Methods: Twenty-five male wistar rats were divided into normal <br /> <br /> control groups, high fat diet rats, drug controls and two dose groups given white turmeric <br /> <br /> extracts. A high-fat diet was given to all groups for ten days to induce insulin resistance, except <br /> <br /> for normal control group. In addition, the drug control group and two dose groups given white <br /> <br /> turmeric extract were intervened for inducers with metformin dose 45 mg/bw, white turmeric <br /> <br /> extract dose 200 mg/bw and 400 mg/bw for ten days. Insulin resistance and its inhibitory <br /> <br /> mechanism are analyzed through fasting blood glucose, insulin, HOMA-IR index, fat profile, <br /> <br /> and tissue morphology in the liver and brain organ. Results: Fasting blood glucose levels of <br /> <br /> rats given white turmeric extract at doses of 400 mg/bw (45.04 ± 9.08 mg/dl) were significantly <br /> <br /> lower (p <0.05) than those in the high-fat diet group (81, 55 ± 13.94 mg/dl), as well as insulin <br /> <br /> levels (1.58 ± 0.37 mU / l, 2.28 ± 0.20 mU / l) and HOMA-IR index (0.17 ± 0.02 ; 0.46 ± 0.08). <br /> <br /> Fat profiles in the group of rats that given the extract were also better and there was a <br /> <br /> morphological difference in the liver and brain tissue between the two groups. The liver cells <br /> <br /> in the high-fat diet group appear larger and the nerve cells with a shorter axon. Conclusion: <br /> <br /> White turmeric extract at doses 400 mg/bw can inhibit the occurrence of insulin resistance <br /> <br /> through improvement of fat profile in male Wistar rats. <br />