FABRICATION OF POLYVINYLPYRROLIDONE/GREEN TEA EXTRACT (PVP/GTE) FIBER BY USING NOZZLELESS ELECTROSPINNING METHODE AS THE MATRIX OF DRUG DELIVERY

• Main Author: WAHIDA (NIM : 20216047), NURUL
• Format: Theses
• Language: Indonesia
• Subjects: Fisika
• Online Access: https://digilib.itb.ac.id/gdl/view/29849
• Institution: Institut Teknologi Bandung

Tea leaves are the source of the world’s most popular beverage and known for its widerange of health benefits since it contains rich amount of polyphenols (catechin). The amount of Polyphenolic compounds in tea leaves are up to 30% in green tea, but only 10% in black tea. One compound group of the polyphenolic compounds known in Green tea are the catechins. Catechins are known to have a relatively high molecular weight (458 g/mol) so only about 0.2-2.0% of the catechins consumed can be absorbed by the blood plasma. Therefore, pure catechins have very slow release profile, in which only 45% of the total amount of catechins that can be released into liposom within 24 hours. To control the dissolution rate of catechins, the composite fibers ofpolyvinylpyrrolidone (PVP)-Green Tea Extract (GTE) were synthesized through electrospinning technique while the PVP was used as the matrix for Green Tea Extract (GTE). To improve the rate of spinning productivity, a new technique of electrospinning was developed, named as nozzleless electrospinning system where no needle is needed and the fibers can be produced from more than one jets. In this experiment, the flowrate was fixed at 30 ?l/m, the distance from the collector to wire was 15 cm and the applied voltage was 15 kV. The solution formula was varied PVP/GTE 12%, 14%, 16%, 18%, 20%, dan 22%. The average of diameters of fiber obtained were then 1,66, 1,55, 1,07, 4,87, 1,35, 1,86, and 1,66 ?m., respectively. In addition, the effects of variation in flowrate and the applied voltage were also observed.