#TITLE_ALTERNATIVE#

• Main Author: DAVITA NIM : 11614033 , PAULINA
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/29919
• Institution: Institut Teknologi Bandung

Epilepsy is a brain disorder characterized by a tendency to cause a continuing epileptic seizure. WHO <br /> <br /> stated in 2018, it is estimated that more than 50 million people in the world are diagnosed with <br /> <br /> epilepsy and 80% are living in developing countries. Phenytoin is a drug with narrow theraupetic index <br /> <br /> that is used in children and adolescents in the form of divided powders or pulveres due to the need <br /> <br /> for small doses which are not available in the market. In the previous study it was found that phenytoin <br /> <br /> divided powders in hospital did not meet the minimum weight of each wrap of divided powders. This <br /> <br /> study was aimed to evaluate the weight variability and content uniformity of the divided powders <br /> <br /> made at its minimum weight. Lactose was used to achieve the minimal weight of the powders. <br /> <br /> Preparations were performed using electronic and manual scale with 2 methods, i.e weighing each <br /> <br /> wrap and ‘blocking and dividing’. Evaluation of the weight of individual wraps was measured with <br /> <br /> analytical scale. The content was measured using a UV-Visible spectrophotometer at 230 nm. Time <br /> <br /> consumed in preparing the divided powder was recorded. Results showed that electronic weighing <br /> <br /> for each package was the best method. Average percentage of CV for weight variation and content <br /> <br /> uniformity was 0.220% and 2.742% with the percentage of powders in the targetted range was 96.66%. <br /> <br /> Statistical analysis using one-way ANOVA showed that there was no statistical difference in all <br /> <br /> methods. Average time consumed for compounding was 28 minutes. <br />