Α - KETOAMIDE SYNTHESIS VIA CUBR 2 CATALYTIC REACTION FROM KETONE AS PRECURSOR

• Main Author: ABDILLAH MUTMAINAH NIM : 10513025, QONITA
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/30060
• Institution: Institut Teknologi Bandung

Abst <br /> <br /> ra <br /> <br /> ct <br /> <br /> The c <br /> <br /> ompounds <br /> <br /> which have <br /> &#945; <br /> <br /> - <br /> <br /> ketoamide functional groups have been known to have <br /> <br /> extensiv <br /> <br /> e biological activity, <br /> <br /> such as <br /> <br /> antiviral, anti <br /> <br /> - <br /> <br /> HIV, antitumor, antibacterial, and <br /> <br /> antiimflammatory <br /> <br /> . Therefore, the development of the synthesis of &#945; <br /> <br /> - <br /> <br /> ketoamide comp <br /> <br /> ounds <br /> <br /> becomes very important. In this study, <br /> <br /> 2 <br /> <br /> - <br /> <br /> bromoacetophenone <br /> <br /> was synthesized from <br /> <br /> styrene <br /> <br /> by bromine addi <br /> <br /> tion reactions, dehydrobromina <br /> <br /> tion <br /> <br /> , and autoxidation by oxygen in <br /> <br /> the <br /> <br /> air. In <br /> <br /> additio <br /> <br /> n, the &#945; <br /> <br /> - <br /> <br /> ketoamide compound was <br /> <br /> synthesized from acetophenone <br /> <br /> and morpholine <br /> <br /> through catalysis reaction <br /> <br /> of <br /> <br /> CuBr <br /> <br /> 2 <br /> <br /> and produced <br /> <br /> 1 <br /> <br /> - <br /> <br /> morpholine <br /> <br /> - <br /> <br /> 2 <br /> <br /> - <br /> <br /> phenylethan <br /> <br /> - <br /> <br /> 1,2 <br /> <br /> - <br /> <br /> dione <br /> <br /> with <br /> <br /> the <br /> <br /> yield of 14%. <br /> <br /> T <br /> <br /> he product of the synthesis was <br /> <br /> purified by column chrom <br /> <br /> atoghraphy and <br /> <br /> pure product was <br /> <br /> characterized by UV <br /> <br /> - <br /> <br /> Vis spectrofotometry, F <br /> <br /> TIR, <br /> <br /> 13 <br /> <br /> C NMR, and <br /> <br /> 1 <br /> <br /> H NMR.