#TITLE_ALTERNATIVE#

• Main Author: PARDILAH NIM : 11613013, RIAN
• Format: Final Project
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/30409
• Institution: Institut Teknologi Bandung

Sonchus arvensis L. leaves has been used traditionally to treat various disease conditions to <br /> <br /> descrease blood preasure and increase urinase. This study was designed to evaluate the <br /> <br /> cardioprotective potential of ethanol extract and water extract of S. arvensis leaves on <br /> <br /> isoproterenol-induced myocardial infarction model rat. Male Wistar albino rats were divided into <br /> <br /> four main groups: negative control (saline only), positive control (isoproterenol only), S. arvensis <br /> <br /> ethanol extract and S. arvensis water extract treated groups. Sonchus arvensis ethanol extract was <br /> <br /> administered in three doses; 50, 100, and 200 mg/kg b.w. and S. arvensis water extract <br /> <br /> administered in one doses ; 100mg/kg b.w p.o for 14 days. On day 13 and 14, isoproterenol (85 <br /> <br /> mg/kg b.w.) was given intraperitoneally to positive control and extract treated groups. The <br /> <br /> parameters studied in this respect were cardiac biomarker enzymes; Creatine Kinase (CK), <br /> <br /> Creatine Kinase-MB (CK-MB), Aspartate Transaminase (AST), Alanine Transaminase (ALT) and <br /> <br /> Lactate Dehydrogenase (LDH). The results showed that S. arvensis ethanol extract at dose of 50 <br /> <br /> mg/kg b.w.and S. arvensis water extract at dose of 100mg/kg b.w. could significantly (P<0.05) <br /> <br /> reduce the level of CK, CK-MB, AST, ALT, and LDH in myocardial infracted rats compared to <br /> <br /> positive control. The increase of the dose of S. arvensis extract was not followed by an increase of <br /> <br /> its cardioprotective activity. In conclusion, Sonchus arvensis L. leaves extract at dose of 50 mg/kg <br /> <br /> b.w. has potency to be developed as candidate of cardioprotective drug. <br />