#TITLE_ALTERNATIVE#

• Main Author: MULYA MIRANTI NIM : 20716030, RIZKA
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/30573
• Institution: Institut Teknologi Bandung

People in West Java consume rice field snail (Filopaludina javanica v.d Busch <br /> <br /> 1844) to prevent and treat peptic ulcers but no scientific studies have proven that <br /> <br /> effect. Activity of the snails as a preventive and gastric ulcer treatment was tested <br /> <br /> by pharmacological testing in acetosal-induced rats. <br /> <br /> Rat-peptic ulcer model was induced with acetosal 405 mg/kg body weight for 10 <br /> <br /> days. In the preventive test, induction was performed 1 hour after administration <br /> <br /> of treatment. In the curative test, induction was done for 10 days then continued <br /> <br /> treatment for 3 days. Each test consisted of 9 groups. Normal group was given <br /> <br /> only 1% CMC solution, the control group was given acetosal, the comparison <br /> <br /> group was given drug suspension (sucralfate dose of 90 mg/kg in preventive test, <br /> <br /> lansoprazole dose of 5 mg/kg on curative test), the test group was given total meat <br /> <br /> the snails doses of 3.310 g/kg and 6.620 g/kg, meat without rectum doses of 2.430 <br /> <br /> g/kg and 4.860 g/kg, rectal doses of 0.790g/kg and 1.580 g/kg. Parameter test <br /> <br /> were based on index ulcer, pH gastric and gastrohistopathology. <br /> <br /> The preventive and curative studies showed that peptic ulcer index in rats of the <br /> <br /> test group were lower than the control group without significant difference (p> <br /> <br /> 0.05), gastric pH measurements showed no significant difference in each <br /> <br /> treatment group and the result of histopathology of the test group showed <br /> <br /> repaired cell in the gastric mucosa. It can be concluded that rice field snail had <br /> <br /> anti-peptic ulcer activity both preventively and curatively. <br />