#TITLE_ALTERNATIVE#

• Main Author: LUCKY RACHMAWAN NIM : 20716022, R.
• Format: Theses
• Language: Indonesia
• Online Access: https://digilib.itb.ac.id/gdl/view/30640
• Institution: Institut Teknologi Bandung

Hypertension is a condition when blood pressure in blood vessels increases <br /> <br /> chronically. This is a high prevalence health problem, which is 25.8%. In society, <br /> <br /> Strobilanthes crispa (L.) Blume leaves are common for kidney stones, diabetic, <br /> <br /> diuretics. This study aims to study Strobilanthes crispa (L.) Blume leaf extract in <br /> <br /> the treatment of hypertension. Testing of antihypertensive effects was carried out <br /> <br /> using indirect measurements in male Wistar rats using a set of Kent Scientific's <br /> <br /> CODA systems and induction using epinephrine 0.5 mg / kg bw. Tests were also <br /> <br /> carried out by using a frog to see information on heart contractions which were <br /> <br /> induced by 2.9 x 10 <br /> <br /> -3 <br /> <br /> mL norepinephrine. Extract test dose to test the <br /> <br /> antihypertensive effect of hexane extract, ethyl acetate extract, ethanol extract and <br /> <br /> water extract respectively 100 mg /kg bw and the comparison used bisoprolol 0.9 <br /> <br /> mg / kg bw to concentrate the heart of frogs, hexane extract, ethyl acetate extract , <br /> <br /> ethanol extract and water extract respectively 0.22 mg / ml. The results showed that <br /> <br /> Strobilanthes crispa (L.) Blume leaf extract possessed antihypertensive activity by <br /> <br /> reducing diastolic blood pressure and systole on all test extracts. The ethyl acetate <br /> <br /> extract of Strobilanthes crispa (L.) Blume leaves at a dose of 100 mg / kg bw gave <br /> <br /> the best results with a percent inhibition of increased diastolic and systolic blood <br /> <br /> pressure which was 20.28% and 19.05% and had a higher inhibitory ability than the <br /> <br /> bisoprolol group 0.9 mg / kg bw but statistically the equivalence between the <br /> <br /> comparison group and ethyl acetate extract of Strobilanthes crispa (L.) Blume <br /> <br /> leaves was 100 mg / kg bw. Strobilanthes crispa (L.) Blume leaf ethyl acetate extract <br /> <br /> produced the best reduction in heart rate frequency from the test extract group with <br /> <br /> a decrease value of 43.72%. Ethyl acetate extract has statistically similar meanings <br /> <br /> (P> 0.05) to the comparative drug group of bisoprolol so as to enable ethyl acetate <br /> <br /> extract to be developed as an antihypertensive drug with beta blocking mechanism <br /> <br /> while hexane, ethanol and water extracts with other mechanisms as <br /> <br /> antihypertension. <br />